Most research on mechanisms of aging is being conducted in a very limited number of
classical model species, ie, laboratory mouse (Mus musculus), rat (Rattus norvegicus …

The oxidative stress theory of aging predicts that manipulations that alter oxidative
stress/damage will alter aging. The gold standard for determining whether aging is altered is …

Lifespan varies within and across species, but the general principles of its control remain
unclear. Here, we conducted multi-tissue RNA-seq analyses across 41 mammalian species …

DNA repair has been hypothesized to be a longevity determinant, but the evidence for it is
based largely on accelerated aging phenotypes of DNA repair mutants. Here, using a panel …

MYC is a highly pleiotropic transcription factor whose deregulation promotes cancer. In
contrast, we find that Myc haploinsufficient (Myc+/–) mice exhibit increased lifespan. They …

Progressive telomere shortening from cell division (replicative aging) provides a barrier for
human tumor progression. This program is not conserved in laboratory mice, which have …

Medicine is an ever-changing science. As new research and clinical experience broaden
our knowledge, changes in treatment and drug therapy are required. The authors and the …

The rate of biological aging is modulated in part by genes interacting with stressor
exposures. Basic research has shown that exposure to short-term stress can strengthen …

Life‐history theory concerns the trade‐offs that mold the patterns of investment by animals
between reproduction, growth, and survival. It is widely recognized that physiology plays a …

Background: Stress is a common reaction to an environmental adversity, but a dysregulation
of the stress response can lead to psychiatric illnesses such as major depressive disorder …