The high-resolution structures of ribosomal subunits published in 2000 have revolutionized
the field of protein translation. They facilitated the determination and interpretation of …

Programmed ribosomal frameshifting (PRF) is one of the multiple translational recoding
processes that fundamentally alters triplet decoding of the messenger RNA by the …

Comparative protein structure modeling predicts the three‐dimensional structure of a given
protein sequence (target) based primarily on its alignment to one or more proteins of known …

EMAN is a scientific image processing package with a particular focus on single particle
reconstruction from transmission electron microscopy (TEM) images. It was first released in …

A novel method to flexibly fit atomic structures into electron microscopy (EM) maps using
molecular dynamics simulations is presented. The simulations incorporate the EM data as …

Cryoelectron microscopy of biological molecules is among the hottest growth areas in
biophysics and structural biology at present, and Frank is arguably the most distinguished …

Exploring recent developments in the field, Coarse-Graining of Condensed Phase and
Biomolecular Systems examines systematic ways of constructing coarse-grained …

During the ribosomal translocation, the binding of elongation factor G (EF-G) to the
pretranslocational ribosome leads to a ratchet-like rotation of the 30S subunit relative to the …

Our understanding of the mechanism of protein synthesis has undergone rapid progress in
recent years as a result of low-resolution X-ray and cryo-EM structures of ribosome …

An 11.7‐Å‐resolution cryo‐EM map of the yeast 80S· eEF2 complex in the presence of the
antibiotic sordarin was interpreted in molecular terms, revealing large conformational …