Age-related diseases are frequently linked to pathological immune dysfunction, including
excessive inflammation, autoreactivity and immunodeficiency. Recent analyses of human …

Clonal hematopoiesis of indeterminate potential (CHIP) describes a widespread expansion
of genetically variant hematopoietic cells that increases exponentially with age and is …

Importance Clonal hematopoiesis of indeterminate potential (CHIP) is associated with
increased risk of atherosclerotic cardiovascular disease, and mouse experiments suggest …

Hematopoietic mosaic loss of Y chromosome (mLOY) is associated with increased risk of
mortality and age-related diseases in men, but the causal and mechanistic relationships …

Deleterious somatic mutations in DNA methyltransferase 3 alpha (DNMT3A) and TET
mehtylcytosine dioxygenase 2 (TET2) are associated with clonal expansion of …

Somatic mosaicism, the occurrence of multiple genetically distinct cell clones within the
same tissue, is an evitable consequence of human aging. The hematopoietic system is no …

Somatic mutations in blood indicative of clonal hematopoiesis of indeterminate potential
(CHIP) are associated with an increased risk of hematologic malignancy, coronary artery …

Age-related changes to the genome-wide DNA methylation (DNAm) pattern observed in
blood are well-documented. Clonal hematopoiesis of indeterminate potential (CHIP) …

Background and Purpose: Clonal hematopoiesis of indeterminate potential (CHIP) is a novel
age-related risk factor for cardiovascular disease–related morbidity and mortality. The …

Clonal hematopoiesis arises from somatic mutations that provide a fitness advantage to
hematopoietic stem cells and the outgrowth of clones of blood cells. Clonal hematopoiesis …