Cisplatin (cis diamminedichloroplatinum II, cDDP) is one of the most effective cancer
chemotherapeutic agents and is used in the treatment of many types of human …

Anticancer drugs are among the most toxic chemicals, which are commercially produced;
therefore, their release in aquatic ecosystems raised concerns in regard to potential adverse …

The evaluation of genotoxicity plays an important role within hazard identification and risk
assessment of chemicals and consumer products. For genotoxicity assessment, in vitro …

The use of chemotherapy agents has been growing worldwide, due to the increase number
of cancer cases. In several countries, mainly in Europe countries, these drugs have been …

Abstract Cyclophosphamide (Cyc) and 5-fluorouracil (5-FU) are two of the most used
antineoplastic drugs (AD) in the world. However, their discharge in the environment became …

Available ecotoxicological data for anti-cancer drugs and their metabolites are incomplete,
and only some studies have been accompanied by chemical analysis. Therefore, the main …

Chemotherapy-associated steatohepatitis is attracting increasing attention because it
heralds an increased risk of morbidity and mortality in patients undergoing surgery because …

The use of anticancer drugs in chemotherapy is increasing, leading to growing
environmental concentrations of imatinib mesylate (IMA), cisplatinum (CDDP), and …

A series of furoxan derivatives of chromone were prepared. The antiproliferative activities
were tested against five cancer cell lines HepG2, MCF-7, HCT-116, B16, and K562, and two …

Over the past 20 years, numerous tyrosine kinase inhibitors (TKIs) have been introduced for
targeted therapy of various types of malignancies. Due to frequent and increasing use …