Age and DNA repair deficiencies are strong risk factors for developing cancer. This is
reflected in the comorbidity of cancer with premature aging diseases associated with DNA …

Mitochondrial dysfunction and oxidative stress have been implicated in the pathogenesis of
a number of diseases and conditions. Oxidative stress occurs once the antioxidant defenses …

Genomic instability and metabolic reprogramming are among the key hallmarks
discriminating cancer cells from normal cells. The two phenomena contribute to the robust …

We investigated potential mechanisms by which elevated glucose may promote genomic
instability. Gene expression studies, protein measurements, mass spectroscopic analyses …

Oxidative stress generated during inflammation is associated with a wide range of
pathologies. Resveratrol (RESV) displays anti-inflammatory and antioxidant activities, being …

Defects in DNA repair pathways and alterations of mitochondrial energy metabolism have
been reported in multiple skin disorders. More than 10% of patients with primary …

Xeroderma pigmentosum complementation group C (XPC) is a DNA damage recognition
protein essential for initiation of global-genomic nucleotide excision repair (GG-NER) …

Significance: The small, multicopy mitochondrial genome (mitochondrial DNA [mtDNA]) is
essential for efficient energy production, as alterations in its coding information or a …

DNA is constantly being damaged, either by endogenous or exogenous genotoxins. In that
regard, DNA repair activities are essential for maintaining genomic stability and to life itself …

As mitochondria are vulnerable to oxidative damage and represent the main source of
reactive oxygen species (ROS), they are considered key tuners of ROS metabolism and …