The primary structure of G proteins as deduced from purified proteins and cloned subunits is
presented. When known, their functions are discussed, as are recent data on direct …

Acute hormonal regulation of liver carbohydrate metabolism mainly involves changes in the
cytosolic levels of cAMP and Ca2+. Epinephrine, acting through beta 2-adrenergic …

Membranes from bovine brain bind relatively large quantities of guanosine 5'-(3-O-thio)
triphosphate (GTP gamma S) with high affinity. The two proteins responsible for most of this …

Mg2+ interacts with the alpha subunits of guanine nucleotide-binding regulatory proteins (G
proteins) in the presence of guanosine-5'-[gamma-thio] triphosphate (GTP-gamma S) to form …

Islet activating protein (IAP), a toxin isolated from Bordetella pertussis, blocks the ability of
inhibitory hormones to attenuate adenylate cyclase activity and enhances the ability of …

Attenuation of GTP-dependent inhibition of adenylate cyclase by islet-activating protein
(pertussis toxin) is due to the ability of the toxin to catalyze the ADP-ribosylation of a …

The regulatory component of adenylate cyclase (G/F) contains the site (s) for activation of the
enzyme by guanine nucleotides. We have developed methods for the assessment of binding …

Treatment of membranes with islet activating protein (IAP), a toxin from Bordetella pertussis,
results in abolition of GTP-dependent, receptor-mediated inhibition of adenylate cyclase …

Activation of the stimulatory guanine nucleotide-binding regulatory component (G/F) of
adenylate cyclase by guanine nucleotides or by Al3+, Mg2+, and F-stabilizes the protein to …

Adenylyl cyclases are under positive and negative control by guanine nucleotides and
hormones1–3. Stimulatory responses are mediated by a guanine nucleotide-and Mg …