The ability of MHC molecules to present a broad spectrum of peptide antigens for T cell
recognition requires a compromise between high affinity and broad specificity. Three …

Unlike their protein “roommates” and their nucleic acid “cousins," carbohydrates remain an
enigmatic arm of biology. The central reason for the difficulty in fully understanding how …

The three-dimensional structure of the class II histocompatibility glycoprotein HLA-DR1 from
human B-cell membranes has been determined by X-ray crystallography and is similar to …

The peptide binding specificities of HLA-DRB1* 0401, DRB1* 0101, and DRB1* 0701 have
been analyzed by the use of large collections of synthetic peptides corresponding to …

PEPTIDES bound to class I molecules are 8–10 amino acids long, and possess a binding
motif representative of peptides that bind to a given class I allele1–4. In the only published …

Pan DR-binding peptides engineered by introducing anchor residues for different DR motifs
within a polyalanine backbone bound 10 of 10 DR molecules tested, with affinities, in most …

Naturally processed peptides were acid extracted from immunoaffinity-purified HLA-DR2,
DR3, DR4, DR7, and DR8. Using the complementary techniques of mass spectrometry and …

Abstract A complex between HLA-DR3 and a fragment of invariant chain called CLIP was
isolated from a human cell line defective in antigen presentation and its X-ray crystal …

Cell surface complexes of class I MHC molecules and bound peptide antigens serve as
specific recognition elements controlling the cytotoxic immune response. The 2.1 A structure …

The structure of a bacterial superantigen, Staphylococcus aureus enterotoxin B, bound to a
human class II histocompatibility complex molecule (HLA-DR1) has been determined by X …