Systematic review of mutations associated with resistance to the new and repurposed Mycobacterium tuberculosis drugs bedaquiline, clofazimine, linezolid …

S Kadura, N King, M Nakhoul, H Zhu… - Journal of …, 2020 - academic.oup.com
Background Improved genetic understanding of Mycobacterium tuberculosis (MTB)
resistance to novel and repurposed anti-tubercular agents can aid the development of rapid …

Molecular Targets Related Drug Resistance Mechanisms in MDR-, XDR-, and TDR-Mycobacterium tuberculosis Strains

HMA Hameed, MM Islam, C Chhotaray… - Frontiers in cellular …, 2018 - frontiersin.org
Tuberculosis (TB) is a formidable infectious disease that remains a major cause of death
worldwide today. Escalating application of genomic techniques has expedited the …

[图书][B] Catalogue of mutations in Mycobacterium tuberculosis complex and their association with drug resistance

World Health Organization - 2023 - books.google.com
Page 1 Catalogue of mutations in Mycobacterium tuberculosis complex and their
association with drug resistance Second edition Page 2 Page 3 Catalogue of mutations in …

Application of next generation sequencing for diagnosis and clinical management of drug-resistant tuberculosis: updates on recent developments in the field

N Dookie, A Khan, N Padayatchi, K Naidoo - Frontiers in Microbiology, 2022 - frontiersin.org
The World Health Organization's End TB Strategy prioritizes universal access to an early
diagnosis and comprehensive drug susceptibility testing (DST) for all individuals with …

Drug resistance mechanisms and drug susceptibility testing for tuberculosis

P Miotto, Y Zhang, DM Cirillo, WC Yam - Respirology, 2018 - Wiley Online Library
Tuberculosis (TB) caused by Mycobacterium tuberculosis (MTB) is the deadliest infectious
disease and the associated global threat has worsened with the emergence of drug …

Tuberculosis drug discovery: Progression and future interventions in the wake of emerging resistance

S Perveen, D Kumari, K Singh, R Sharma - European Journal of Medicinal …, 2022 - Elsevier
The emergence of drug resistance continues to afflict TB control where drug resistant strains
have become a global health concern. Contrary to drug-sensitive TB, the treatment of …

Drug resistance mechanisms and novel drug targets for tuberculosis therapy

MM Islam, HMA Hameed, J Mugweru… - Journal of genetics and …, 2017 - Elsevier
Drug-resistant tuberculosis (TB) poses a significant challenge to the successful treatment
and control of TB worldwide. Resistance to anti-TB drugs has existed since the beginning of …

Role of post‐translational modifications in the acquisition of drug resistance in Mycobacterium tuberculosis

G Arora, A Bothra, G Prosser, K Arora… - The FEBS …, 2021 - Wiley Online Library
Tuberculosis (TB) is one of the primary causes of deaths due to infectious diseases. The
current TB regimen is long and complex, failing of which leads to relapse and/or the …

Recent advances in molecular diagnostics and understanding mechanisms of drug resistance in nontuberculous mycobacterial diseases

HJ Huh, SY Kim, BW Jhun, SJ Shin, WJ Koh - Infection, Genetics and …, 2019 - Elsevier
Accumulating evidence suggests that human infections caused by nontuberculous
mycobacteria (NTM) are increasing worldwide, indicating that NTM disease is no longer …

Activity of LCB01-0371, a novel oxazolidinone, against Mycobacterium abscessus

TS Kim, JH Choe, YJ Kim, CS Yang… - Antimicrobial agents …, 2017 - Am Soc Microbiol
Mycobacterium abscessus is a highly pathogenic drug-resistant rapidly growing
mycobacterium. In this study, we evaluated the in vitro, intracellular, and in vivo activities of …