Alternative splicing is one of the most important mechanisms to generate a large number of
mRNA and protein isoforms from the surprisingly low number of human genes. Unlike …

The past year has witnessed refinements in models of spliceosome assembly pathways and
in the understanding of how splicing factors of the serine/arginine-rich (SR) protein family …

Many eukaryotic genes generate linear mRNAs and circular RNAs, but it is largely unknown
how the ratio of linear to circular RNA is controlled or modulated. Using RNAi screening in …

Haplodiploid organisms comprise about 20% of animals. Males develop from unfertilized
eggs while females are derived from fertilized eggs. The underlying mechanisms of sex …

Regulation of gene expression at the post-transcriptional level is mainly achieved by
proteins containing well-defined sequence motifs involved in RNA binding. The most widely …

We have searched the human genome for genes encoding new proteins that may be
involved in three nuclear gene expression processes: transcription, pre-messenger RNA …

Alternative splicing is thought to be regulated by nonspliceosomal RNA binding proteins that
modulate the association of core components of the spliceosome with the pre-mRNA …

Comprehensive proteomics analyses of spliceosomal complexes are currently limited to
those in humans, and thus, it is unclear to what extent the spliceosome's highly complex …

A total of 74 small nuclear RNA (snRNA) genes and 395 genes encoding splicing-related
proteins were identified in the Arabidopsis genome by sequence comparison and motif …

Research into the origins of introns is at a critical juncture in the resolution of theories on the
evolution of early life (which came first, RNA or DNA?), the identity of LUCA (the last …