Aptamers as targeted therapeutics: current potential and challenges

J Zhou, J Rossi - Nature reviews Drug discovery, 2017 - nature.com
Nucleic acid aptamers, often termed'chemical antibodies', are functionally comparable to
traditional antibodies, but offer several advantages, including their relatively small physical …

Hybridization chain reaction: a versatile molecular tool for biosensing, bioimaging, and biomedicine

S Bi, S Yue, S Zhang - Chemical Society Reviews, 2017 - pubs.rsc.org
Developing powerful, simple and low-cost DNA amplification techniques is of great
significance to bioanalysis and biomedical research. Thus far, many signal amplification …

[HTML][HTML] Uptake, functionality, and re-release of extracellular vesicle-encapsulated cargo

K O'Brien, S Ughetto, S Mahjoum, AV Nair… - Cell reports, 2022 - cell.com
Extracellular vesicles (EVs) are membrane-encapsulated particles that carry genetically
active and protein/lipid cargo that can affect the function of the recipient cell. A number of …

Aptamer/AuNP biosensor for colorimetric profiling of exosomal proteins

Y Jiang, M Shi, Y Liu, S Wan, C Cui… - Angewandte Chemie …, 2017 - Wiley Online Library
Exosomes constitute an emerging biomarker for cancer diagnosis because they carry
multiple proteins that reflect the origins of parent cells. Assessing exosome surface proteins …

[HTML][HTML] Aptamer-functionalized nanoparticles in targeted delivery and cancer therapy

Z Fu, J Xiang - International Journal of Molecular Sciences, 2020 - mdpi.com
Using nanoparticles to carry and delivery anticancer drugs holds much promise in cancer
therapy, but nanoparticles per se are lacking specificity. Active targeting, that is, using …

Self-assembled, aptamer-tethered DNA nanotrains for targeted transport of molecular drugs in cancer theranostics

G Zhu, J Zheng, E Song, M Donovan… - Proceedings of the …, 2013 - National Acad Sciences
Nanotechnology has allowed the construction of various nanostructures for applications,
including biomedicine. However, a simple target-specific, economical, and biocompatible …

Cancer‐targeting nanoparticles for combinatorial nucleic acid delivery

HJ Vaughan, JJ Green, SY Tzeng - Advanced Materials, 2020 - Wiley Online Library
Nucleic acids are a promising type of therapeutic for the treatment of a wide range of
conditions, including cancer, but they also pose many delivery challenges. For efficient and …

Programmable and multifunctional DNA‐based materials for biomedical applications

Y Zhang, J Tu, D Wang, H Zhu, SK Maity… - Advanced …, 2018 - Wiley Online Library
DNA encodes the genetic information; recently, it has also become a key player in material
science. Given the specific Watson–Crick base‐pairing interactions between only four types …

Noncanonical self-assembly of multifunctional DNA nanoflowers for biomedical applications

G Zhu, R Hu, Z Zhao, Z Chen, X Zhang… - Journal of the American …, 2013 - ACS Publications
DNA nanotechnology has been extensively explored to assemble various functional
nanostructures for versatile applications. Mediated by Watson–Crick base-pairing, these …

Aptamers generated from cell-SELEX for molecular medicine: a chemical biology approach

X Fang, W Tan - Accounts of chemical research, 2010 - ACS Publications
Molecular medicine is an emerging field focused on understanding the molecular basis of
diseases and translating this information into strategies for diagnosis and therapy. This …