Neurological disorders represent major health concerns in terms of comorbidity and
mortality worldwide. Despite a tremendous increase in our understanding of the …

Acute ischemic stroke and traumatic brain injury are a major cause of mortality and
morbidity. Due to the paucity of therapies, there is a pressing clinical demand for new …

Neuroprotection is a desirable process in many neurological disorders, yet complex
mechanisms involved in this field are not completely understood. The pilocarpine epilepsy …

The kallikrein-kinin system (KKS) is an intricate endogenous pathway involved in several
physiological and pathological cascades in the brain. Due to the pathological effects of …

Statins may act on inflammatory responses, decreasing oxidative stress and also reducing
brain inflammation in several brain disorders. Epileptogenesis is a process in which a …

The mediatory role of kinins in both acute and chronic inflammation within nervous tissues
has been widely described. Bradykinin, the major representative of these bioactive peptides …

We previously showed that patients with temporal lobe epilepsy (TLE) present an increased
expression of angiotensin II (AngII) AT1 and AT2 receptors in the hippocampus, supporting …

Bradykinin (BK) and its receptors (B1 and B2) may exert a role in the pathophysiology of
certain CNS diseases, including epilepsy. In healthy tissues, B2 receptors are constitutively …

The aim of this study was to analyze the expression of survival-related molecules such Akt
and integrin-linked kinase (ILK) to evaluate Akt pathway activation in epileptogenesis …

Physical exercise is a strong external effector that induces precursor cell proliferation in the
adult mouse hippocampus. Research into mechanisms has focused on central changes …