Nerve growth factor (NGF) is a neurotrophin that activates nociceptive neurons to transmit
pain signals from the peripheral to the central nervous system and that exerts its effects on …

The highly disagreeable sensation of pain results from an extraordinarily complex and
interactive series of mechanisms integrated at all levels of the neuroaxis, from the periphery …

The primary sensory system requires the integrated function of multiple cell types, although
its full complexity remains unclear. We used comprehensive transcriptome analysis of 622 …

Neuropathy is the most common and debilitating complication of diabetes and results in
pain, decreased motility, and amputation. Diabetic neuropathy encompasses a variety of …

TRPA1, a member of the transient receptor potential (TRP) family of ion channels, is
expressed by dorsal root ganglion neurons and by cells of the inner ear, where it has …

Nerve growth factor (NGF) antagonism is on the verge of becoming a powerful analgesic
treatment for numerous conditions, including osteoarthritis and lower back pain. This review …

Brain-derived neurotrophic factor (BDNF), a member of the neurotrophin family, plays critical
roles in the survival, growth, and maintenance of brain and peripheral neurons. We report …

DURING the initial phase of their development, sensory neurons of the dorsal root ganglion
(DRG) require target-derived trophic support for their survival1–3, but as they mature they …

The release of glutamate during brain anoxia or ischaemia triggers the death of neurons,
causing mental or physical handicap. The mechanism of glutamate release is controversial …

The neurotrophin family of neurotrophic factors are well-known for their effects on neuronal
survival and growth. Over the past decade, considerable evidence has accumulated from …