In this work, the discovery and description of PF‐07321332, a major bioavailable oral SARS‐
CoV‐2 protease inhibitor with in vitro human coronavirus antiviral activity, and excellent …

A new coronavirus (CoV) caused a pandemic named COVID-19, which has become a
global health care emergency in the present time. The virus is referred to as SARS-CoV-2 …

The uncontrolled spread of the COVID-19 pandemic caused by the new coronavirus SARS-
CoV-2 during 2020–2021 is one of the most devastating events in the history, with …

The novel coronavirus whose outbreak took place in December 2019 continues to spread at
a rapid rate worldwide. In the absence of an effective vaccine, inhibitor repurposing or de …

Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2). The viral outbreak started in late 2019 and rapidly became a …

Since its outbreak in late 2019, the COVID-19 pandemic has drawn enormous attention
worldwide as a consequence of being the most disastrous infectious disease in the past …

The SARS‐CoV‐2 main protease (Mpro) cleaves along the two viral polypeptides to release
non‐structural proteins required for viral replication. MPro is an attractive target for antiviral …

The emergence of a variety of coronaviruses (CoVs) in the last decades has posed huge
threats to human health. Especially, the ongoing pandemic of coronavirus disease 2019 …

Various computational studies, including in silico ones, have identified several existing
compounds that could serve as effective inhibitors of the SARS-CoV-2 main protease …

SARS-CoV-2 pandemic in the end of 2019 led to profound consequences on global health
and economy. Till producing successful vaccination strategies, the healthcare sectors …