The nuclear genomes of vertebrates are mosaics of isochores, very long stretches (≫
300kb) of DNA that are homogeneous in base composition and are compositionally …

To show that the input pattern of chromosomal mutations is highly organized relative to the
band patterns along human chromosomes, a new term," metaphase chromatin flavor," is …

Vertebrate genomes are mosaics of isochores--namely, of long (> 300 kb), compositionally
homogeneous DNA segments that can be subdivided into a small number of families …

The term genome was first introduced by German botanist Hans Winkler in the early 19th
century to describe the eukaryotic chromosome. It gained considerable attention through the …

Chromosome in situ suppression hybridization has been carried out on human metaphase
chromosomes to localize the G+ C-richest human DNA fraction (which only represents 3.5 …

Previous investigations on the human genome determined:(i) the base compositions (GC
levels) and the relative amounts of its isochore families;(ii) the compositional correlations (ie …

Structural genomics is the study of the DNA of living organisms. Evolutionary genomics is
the study of the history of the genome. These subjects are closely interlinked. They are …

Linear correlations exist between the GC levels of third codon positions (GC3) of individual
human genes and the GC levels of long genomic sequences and DNA molecules (50–100 …

cDNA selection was used to isolate coding sequences from cosmids mapping to the gene-
rich telomeric region of human chromosome 21q. A novel cDNA, termedSMT3A, was …

The human genome is made up of long DNA segments, the isochores, which are
compositionally homogeneous and can be subdivided into a small number of families …