Mammalian copper homeostasis: physiological roles and molecular mechanisms

S Lutsenko, S Roy, P Tsvetkov - Physiological Reviews, 2025 - journals.physiology.org
In the past decade, evidence for the numerous roles of copper (Cu) in mammalian
physiology has grown exponentially. The discoveries of Cu involvement in cell signaling …

Role of copper in central nervous system physiology and pathology

M Locatelli, C Farina - Neural Regeneration Research, 2025 - journals.lww.com
Copper is a transition metal and an essential element for the organism, as alterations in its
homeostasis leading to metal accumulation or deficiency have pathological effects in …

Decreased spinal cord motor neuron numbers in mice depleted of central nervous system copper

JR Liddell, JBW Hilton, YJ Wang, JL Billings… - Metallomics, 2024 - academic.oup.com
Disrupted copper availability in the central nervous system (CNS) is implicated as a
significant feature of the neurodegenerative disease amyotrophic lateral sclerosis (ALS) …

[HTML][HTML] Integrated elemental analysis supports targeting copper perturbations as a therapeutic strategy in multiple sclerosis

JBW Hilton, K Kysenius, JR Liddell, SW Mercer… - …, 2024 - Elsevier
Multiple sclerosis (MS) is a debilitating affliction of the central nervous system (CNS) that
involves demyelination of neuronal axons and neurodegeneration resulting in disability that …

X-ray fluorescence mapping of brain tissue reveals the profound extent of trace element dysregulation in stroke pathophysiology

MJ Pushie, NJ Sylvain, H Hou, N Pendleton… - Metallomics, 2024 - academic.oup.com
The brain is a privileged organ with regard to its trace element composition and maintains a
robust barrier system to sequester this specialized environment from the rest of the body and …

Titration of cuprizone induces reliable demyelination

N Wigger, J Krüger, E Vankriekelsvenne, M Kipp - Brain Research, 2024 - Elsevier
Multiple Sclerosis (MS) is a chronic inflammatory disease of the central nervous system.
Cuprizone-induced demyelination, wherein mice are fed a diet containing the copper …

[HTML][HTML] The application of X-ray fluorescence microscopy and micro-XANES spectroscopy to study neuro-metallomics

M Willans, A Hollings, RE Boseley, T Munyard… - Journal of Inorganic …, 2024 - Elsevier
This early career research highlight provides a review of my own research program over the
last decade, a time frame that encompasses my transition from postdoctoral fellowships to …