Repurposing amino-bisphosphonates by liposome formulation for a new role in cancer treatment

NM La-Beck, X Liu, H Shmeeda, C Shudde… - Seminars in Cancer …, 2021 - Elsevier
Abstract Amino-bisphosphonates (N-BPs) have been commercially available for over four
decades and are used for the treatment of osteoporosis, Paget's disease, hypercalcemia of …

Gastrointestinal tract and the mucosal macrophage reservoir in HIV infection

D Brown, JJ Mattapallil - Clinical and Vaccine Immunology, 2014 - Am Soc Microbiol
The gastrointestinal tract (GIT) is a primary site for human immunodeficiency virus (HIV) and
simian immunodeficiency virus (SIV) infection, replication, and dissemination. After an initial …

Maternal Western-style diet remodels the transcriptional landscape of fetal hematopoietic stem and progenitor cells in rhesus macaques

S Sureshchandra, CN Chan, JJ Robino, LK Parmelee… - Stem Cell Reports, 2022 - cell.com
Maternal obesity adversely impacts the in utero metabolic environment, but its effect on fetal
hematopoiesis remains incompletely understood. During late development, the fetal bone …

Long-term hepatitis B virus infection of rhesus macaques requires suppression of host immunity

S Biswas, LN Rust, JM Wettengel, S Yusova… - Nature …, 2022 - nature.com
Hepatitis B virus has infected a third of the world's population, and 296 million people are
living with chronic infection. Chronic infection leads to progressive liver disease, including …

Macrophage apoptosis using alendronate in targeted nanoarchaeosomes

HE Jerez, MJ Altube, YB Gándola, L Gonzalez… - European Journal of …, 2021 - Elsevier
Nanoarchaeosomes are non-hydrolysable nanovesicles made of archaeolipids, naturally
functionalised with ligand for scavenger receptor class 1. We hypothesized that nitrogenate …

Nano-technology based carriers for nitrogen-containing bisphosphonates delivery as sensitisers of γδ T cells for anticancer immunotherapy

NO Hodgins, JTW Wang, KT Al-Jamal - Advanced Drug Delivery Reviews, 2017 - Elsevier
Nitrogen containing bisphosphonates (N-BPs) including zoledronate (ZOL) and alendronate
(ALD) inhibit farnesyl diphosphate synthase, and have been shown to have a cytotoxic affect …

[HTML][HTML] In vitro potency, in vitro and in vivo efficacy of liposomal alendronate in combination with γδ T cell immunotherapy in mice

NO Hodgins, JTW Wang, AC Parente-Pereira… - Journal of Controlled …, 2016 - Elsevier
Nitrogen-containing bisphosphonates (N-BP), including zoledronic acid (ZOL) and
alendronate (ALD), have been proposed as sensitisers in γδ T cell immunotherapy in pre …

Allogeneic stem cell transplantation in fully MHC-matched Mauritian cynomolgus macaques recapitulates diverse human clinical outcomes

BJ Burwitz, HL Wu, S Abdulhaqq… - Nature …, 2017 - nature.com
Allogeneic hematopoietic stem cell transplantation (HSCT) is a critically important therapy
for hematological malignancies, inborn errors of metabolism, and immunodeficiency …

Strategies to target non-T-cell HIV reservoirs

JB Sacha, LC Ndhlovu - Current Opinion in HIV and AIDS, 2016 - journals.lww.com
Strategies to target non-T-cell HIV reservoirs : Current Opinion in HIV and AIDS Strategies to
target non-T-cell HIV reservoirs : Current Opinion in HIV and AIDS Log in or Register Subscribe …

Western‐style diet in the presence of elevated circulating testosterone induces adipocyte hypertrophy without proinflammatory responses in rhesus macaques

BJ Burwitz, S Yusova, JJ Robino… - American Journal of …, 2023 - Wiley Online Library
Problem Anovulatory infertility is commonly associated with hyperandrogenemia (elevated
testosterone, T), insulin resistance, obesity, and white adipose tissue (WAT) dysfunction …