Prognostic role of survivin in bladder cancer: a systematic review and meta-analysis

C Jeon, M Kim, C Kwak, HH Kim, JH Ku - PloS one, 2013 - journals.plos.org
Purpose The objective of the present study was to conduct a systematic review and meta-
analysis of published literature investigating the survivin expression and its effects on …

[HTML][HTML] Survivin as a potential target for cancer therapy

E Soleimanpour, E Babaei - Asian Pacific Journal of Cancer …, 2015 - koreascience.kr
In 1997 for the first time, survivin was described by Amborsini et al. as an anti-apoptotic
protein. Subsequent studies revealed that survivin is a multifunctional protein that plays …

Prognostic significance of survivin expression in renal cell cancer and its correlation with radioresistance

Y Lei, Z Geng, W Guo-Jun, W He, Y Jian-Lin - Molecular and cellular …, 2010 - Springer
Survivin, an important inhibitor of apoptosis, has been found to play an important role in the
initiation, progression, and chemoradioresistance of human malignancies. Previously, we …

YM155, a novel survivin suppressant, enhances taxane-induced apoptosis and tumor regression in a human Calu 6 lung cancer xenograft model

T Nakahara, K Yamanaka, S Hatakeyama… - Anti-cancer …, 2011 - journals.lww.com
Survivin, an apoptotic inhibitor, is overexpressed in the majority of human tumor types and
represents a novel target for anticancer therapy. Taxanes induce a mitotic cell-cycle block …

Genetic and molecular biology of bladder cancer among Iranian patients

M Mojarrad, M Moghbeli - Molecular genetics & genomic …, 2020 - Wiley Online Library
Background Bladder cancer (BC) is the sixth common cancer among Iranians. Various risk
factors such as smoking, body mass index, chronic infection, age, and genetic factors are …

Protein Sam68 regulates the alternative splicing of survivin DEx3

J Gaytan-Cervantes, C Gonzalez-Torres… - Journal of Biological …, 2017 - ASBMB
Messenger RNA alternative splicing (AS) regulates the expression of a variety of genes
involved in both physiological and pathological processes. AS of the anti-apoptotic and …

Overexpression of survivin levels in circulation and tissue samples of lung cancer patients

G Kapellos, K Polonifi, D Farmakis… - Anticancer …, 2013 - ar.iiarjournals.org
Background: Survivin, an apoptosis inhibitor protein, has multiple functions that favor cancer
cell survival. We sought to determine survivin levels in blood samples and biopsies from …

Molecular characterization of upper urinary tract tumours

L Izquierdo, L Mengual, C Gazquez… - BJU …, 2010 - Wiley Online Library
OBJECTIVES To assess gene‐expression patterns of BIRC5, FGFR3, IGF2, KRT20, UPK2,
EBF1, CDH1, FXYD3, HTERT, TP53, AGR2, HER2 and VEGF, widely known markers of …

Survivin splice variants are not essential for mitotic progression or inhibition of apoptosis induced by doxorubicin and radiation

NK Jacob, JV Cooley, K Shirai… - OncoTargets and …, 2012 - Taylor & Francis
Survivin is a critical regulator of mitosis, and an inhibitor of apoptosis which is
overexpressed in almost all cancers. In the current study, cell cycle profiles of normal …

Nuclear, but not cytoplasmic, localization of survivin as a negative prognostic factor for survival in upper urinary tract urothelial carcinoma

H Kitamura, T Torigoe, Y Hirohashi, H Asanuma… - Virchows Archiv, 2013 - Springer
Survivin, a member of the inhibitor of apoptosis protein gene family, inhibits apoptosis and
promotes mitosis. We determined whether nuclear or cytoplasmic localization of survivin …