Nanomedicine for brain cancer
CNS tumors remain among the deadliest forms of cancer, resisting conventional and new
treatment approaches, with mortality rates staying practically unchanged over the past 30 …
treatment approaches, with mortality rates staying practically unchanged over the past 30 …
Circular RNA-encoded oncogenic E-cadherin variant promotes glioblastoma tumorigenicity through activation of EGFR–STAT3 signalling
Activated EGFR signalling drives tumorigenicity in 50% of glioblastoma (GBM). However,
EGFR-targeting therapy has proven ineffective in treating patients with GBM, indicating that …
EGFR-targeting therapy has proven ineffective in treating patients with GBM, indicating that …
[HTML][HTML] Glioma stem cells as immunotherapeutic targets: advancements and challenges
Glioblastoma is the most common and lethal primary brain malignancy. Despite major
investments in research into glioblastoma biology and drug development, treatment remains …
investments in research into glioblastoma biology and drug development, treatment remains …
Multi-omics immune interaction networks in lung cancer tumorigenesis, proliferation, and survival
Q Ye, J Hickey, K Summers, B Falatovich… - International journal of …, 2022 - mdpi.com
There are currently no effective biomarkers for prognosis and optimal treatment selection to
improve non-small cell lung cancer (NSCLC) survival outcomes. This study further validated …
improve non-small cell lung cancer (NSCLC) survival outcomes. This study further validated …
[HTML][HTML] SPI1-mediated MIR222HG transcription promotes proneural-to-mesenchymal transition of glioma stem cells and immunosuppressive polarization of …
Y Fan, Z Gao, J Xu, H Wang, Q Guo, B Li, M Li, H Xu… - Theranostics, 2023 - ncbi.nlm.nih.gov
Background: Glioma stem cells (GSCs) are a key factor in glioblastoma (GBM) development
and treatment resistance. GSCs can be divided into the mesenchymal (MES) and proneural …
and treatment resistance. GSCs can be divided into the mesenchymal (MES) and proneural …
Small extracellular vesicles promote invadopodia activity in glioblastoma cells in a therapy-dependent manner
Purpose The therapeutic efficacy of radiotherapy/temozolomide treatment for glioblastoma
(GBM) is limited by the augmented invasiveness mediated by invadopodia activity of …
(GBM) is limited by the augmented invasiveness mediated by invadopodia activity of …
Distinct cell adhesion signature defines glioblastoma myeloid-derived suppressor cell subsets
In multiple types of cancer, an increased frequency in myeloid-derived suppressor cells
(MDSC) is associated with worse outcomes and poor therapeutic response. In the …
(MDSC) is associated with worse outcomes and poor therapeutic response. In the …
Endothelial, pericyte and tumor cell expression in glioblastoma identifies fibroblast activation protein (FAP) as an excellent target for immunotherapy
Objectives Targeted immunotherapies such as chimeric antigen receptor (CAR)‐T cells are
emerging as attractive treatment options for glioblastoma, but rely on identification of a …
emerging as attractive treatment options for glioblastoma, but rely on identification of a …
LGR6 activates the Wnt/β-catenin signaling pathway and forms a β-catenin/TCF7L2/LGR6 feedback loop in LGR6high cervical cancer stem cells
Q Feng, S Li, HM Ma, WT Yang, PS Zheng - Oncogene, 2021 - nature.com
The leucine-rich repeat-containing G-protein-coupled receptor 6 (LGR6) is considered to be
a stem cell marker in many normal tissues and promotes tissue development, regeneration …
a stem cell marker in many normal tissues and promotes tissue development, regeneration …
Glycomaterials to investigate the functional role of aberrant glycosylation in Glioblastoma
C Tondepu, L Karumbaiah - Advanced healthcare materials, 2022 - Wiley Online Library
Glioblastoma (GBM) is a stage IV astrocytoma that carries a dismal survival rate of≈ 10
months postdiagnosis and treatment. The highly invasive capacity of GBM and its ability to …
months postdiagnosis and treatment. The highly invasive capacity of GBM and its ability to …