Type II topoisomerases (TOP2) are conserved regulators of chromatin topology that catalyze
reversible DNA double-strand breaks (DSBs) and are essential for maintaining genomic …

Simple Summary Cells need to produce ribosomes to sustain continuous proliferation and
expand in numbers, a feature that is even more prominent in uncontrollably proliferating …

The chemotherapeutic agent CX-5461, or pidnarulex, has been fast-tracked by the United
States Food and Drug Administration for early-stage clinical studies of BRCA1-, BRCA2-and …

Abstract CX-3543 (Quarfloxin) and CX-5461 (Pidnarulex) were originally derived from a
group of fluoroquinolones that were shown to have dual topoisomerase II (Top2) and G …

Embryonic development is dictated by tight regulation of DNA replication, cell division and
differentiation. Mutations in DNA repair and replication genes disrupt this equilibrium, giving …

DNA–protein crosslinks (DPCs) are toxic DNA lesions wherein a protein is covalently
attached to DNA. If not rapidly repaired, DPCs create obstacles that disturb DNA replication …

Besides the canonical function in ribosome biogenesis, there have been significant recent
advances towards the fascinating roles of the nucleolus in stress response, cell destiny …

CX-5461 is a G-quadruplex stabilizer that exhibits synthetic lethality in homologous
recombination-deficient models. In this multicentre phase I trial in patients with solid tumors …

Co-transcriptional RNA-DNA hybrids can not only cause DNA damage threatening genome
integrity but also regulate gene activity in a mechanism that remains unclear. Here, we show …

Guanine-rich DNA sequences can fold into stable four-stranded structures called G-
quadruplexes or G4s. Research in the past decade demonstrated that G4 structures are …