Many chronic diseases are marked by fibrosis, which is defined by an abundance of
activated fibroblasts and excessive deposition of extracellular matrix, resulting in loss of …

The fibrotic process could be easily defined as a pathological excess of extracellular matrix
deposition, leading to disruption of tissue architecture and eventually loss of function; …

Mitophagy, by maintaining mitochondrial quality control, plays a key role in maintaining
kidney function and is impaired in pathologic states. Macrophages are well known for their …

Aims This study aimed to explore the possible mechanism of trauma-induced
laryngotracheal stenosis and potential protective and therapeutic efficacy of quercetin on …

The interaction between adherent-invasive Escherichia coli (AIEC) and intestinal
macrophages is implicated in the pathogenesis of Crohn's disease (CD). However, its role in …

Chronic kidney disease (CKD) is a major cause of morbidity and mortality worldwide,
imposing a great burden on the healthcare system. Regrettably, effective CKD therapeutic …

Our previously published study demonstrated that mammalian target of rapamycin complex
2 (mTORC2) signaling mediates TGFβ1-induced fibroblast activation. However, the …

OBJECTIVE: Adrenergic receptors belong to the G protein-coupled receptor family and are
one of the important targets of modern drug therapy. Dexmedetomidine (DEX) is a highly …

The realization that cellular metabolism dictates immune cell development, differentiation
and function affords metabolic intervention as a potential venue for cancer immunotherapy …

The mammalian target of rapamycin (mTOR), a serine/threonine protein kinase, is crucial in
regulating cell growth, metabolism, proliferation, and survival. Under physiologic conditions …