Liquid–liquid phase separation (LLPS) is a novel principle for explaining the precise spatial
and temporal regulation in living cells. LLPS compartmentalizes proteins and nucleic acids …

Liquid–liquid phase separation (LLPS) is an emerging phenomenon in cell physiology and
diseases. The weak multivalent interaction prerequisite for LLPS is believed to be facilitated …

Abstract hnRNPA2 is a human ribonucleoprotein (RNP) involved in RNA metabolism. It
forms fibrils both under cellular stress and in mutated form in neurodegenerative conditions …

Protein domains without the usual distribution of amino acids, called low complexity (LC)
domains, can be prone to self-assembly into amyloid-like fibrils. Self-assembly of LC …

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder whose exact
causative mechanisms are still under intense investigation. Several lines of evidence …

Fused in sarcoma (FUS), a nuclear RNA binding protein, can not only undergo liquid–liquid
phase separation (LLPS) to form dynamic biomolecular condensates but also aggregate into …

Mitigation of biofouling and the host's foreign body response (FBR) is a critical challenge
with biomedical implants. The surface coating with various anti-fouling materials provides a …

FUS is a multifunctional nuclear protein which undergoes liquid–liquid phase separation in
response to stress and DNA damage. Dysregulation of FUS dynamic phase separation …

Liquid-liquid phase separation (LLPS) of proteins mediates the assembly of biomolecular
condensates involved in physiological and pathological processes. Identifying the …

A subset of the proteins found in pathological protein fibrils also exhibit tendencies for liquid-
liquid phase separation (LLPS) both in vitro and in cells. The mechanisms underlying the …