Nontuberculous mycobacteria (NTM) are emerging human pathogens, causing a wide
range of clinical diseases affecting individuals who are immunocompromised and who have …

The mammalian immune system comprises an adaptive and an innate component. The
innate immune system employs a limited number of germ-line-encoded pattern-recognition …

The search for common host mechanisms that recognize human fungal pathogens as non‐
self has led to an increased interest in cell wall polysaccharides since they are absent from …

Dendritic cell-associated C-type lectin-1 (Dectin-1), also known as β-glucan receptor is an
emerging pattern recognition receptor (PRR) which belongs to the family of C-type lectin …

Novel vaccination strategies against Mycobacterium tuberculosis (MTB) are urgently
needed. The use of recombinant MTB antigens as subunit vaccines is a promising …

The β-glucan receptor Dectin-1 is an archetypical non-toll-like pattern recognition receptor
expressed predominantly by myeloid cells, which can induce its own intracellular signalling …

β‐Glucans are naturally occurring carbohydrates that possess immune‐modulating
activities, but their mechanisms of action are largely unknown. Recent discoveries, however …

Mycobacterium abscessus (M. abscessus) is an opportunistic pathogen usually colonizing
abnormal lung airways and is often seen in patients with cystic fibrosis. Currently, there is no …

TLRs play a major role in microbe-host interactions and innate immunity. Of the 10 functional
TLRs described in humans, TLR2 is unique in its requirement to form heterodimers with …

Mycobacteria are a genus of bacteria that range from the non‐pathogenic M ycobacterium
smegmatis to M ycobacterium tuberculosis, the causative agent of tuberculosis in humans …