Infections due to carbapenem-resistant Enterobacteriaceae (CRE) are increasingly
prevalent in children and are associated with poor clinical outcomes. Optimal treatment …

The availability of sensitive, accurate and specific analytical methods for the measurement of
polymyxins in biological fluids has enabled an understanding of the pharmacokinetics of …

Welcome to the 29th edition of Nelson's Pediatric Antimicrobial Therapy, the third edition
written during the COVID-19 pandemic, which continues to significantly affect our lives and …

Antimicrobial resistance poses a substantial threat to global public health. The pursuit of
new antibiotics has decreased and very few options have been investigated for the …

Limited pharmacokinetic (PK) data suggest that currently recommended pediatric dosages
of colistimethate sodium (CMS) by the Food and Drug Administration and European …

Background Intravenous colistin is widely used to treat infections in pediatric patients.
Unfortunately, there is a paucity of pharmacological information to guide the selection of …

This document provides interim recommendations for appropriate colistin use (polymyxin E)
to treat bacterial infections in neonates, infants, and children. Colistin, a polymyxin antibiotic …

In the last years, there has been a tremendous increase in the incidence of bacterial
infections due to resistant strains, especially multi-drug resistant Gram-negative bacilli. In …

Use of colistin in children is rising in line with the increase of multidrug-resistant Gram-
negative bacteria (MDR-GNB). In adults, a colistin loading dose is recommended to achieve …

Completely updated and revised, the 29th edition of this best-selling reference provides
instant access to the latest recommendations for treatment of infectious diseases in children …