Glucokinase is a key regulatory enzyme in the pancreatic beta‐cell. It plays a crucial role in
the regulation of insulin secretion and has been termed the glucose sensor in pancreatic …

This review focuses on the human pancreatic islet—including its structure, cell composition,
development, function, and dysfunction. After providing a historical timeline of key …

Background Glucokinase (GCK) regulates insulin secretion to maintain appropriate blood
glucose levels. Sequence variants can alter GCK activity to cause hyperinsulinemic …

Although elevated levels of C-reactive protein (CRP) independently predict increased risk of
development of metabolic syndrome, diabetes, myocardial infarction, and stroke …

Aims/hypothesis MODY is mainly characterised by an early onset of diabetes and a positive
family history of diabetes with an autosomal dominant mode of inheritance. However, de …

Paralleling the increasing trends of maternal obesity, gestational diabetes (GDM) has
become a global health challenge with significant public health repercussions. In addition to …

Objective The aim of this study was to group patients with MODY (maturity‐onset diabetes of
the young) according to the genetic alterations underlying the disease and to investigate …

Background Maturity‐onset diabetes of the young (MODY) is a form of monogenic diabetes
with autosomal dominant inheritance. To date, mutations in 11 genes have been frequently …

Mutations in glucokinase (GCK) cause a spectrum of glycemic disorders. Heterozygous loss-
of-function mutations cause mild fasting hyperglycemia irrespective of mutation severity due …

Understanding how cell subpopulations in a tissue impact overall system function is
challenging. There is extensive heterogeneity among insulin-secreting β-cells within islets of …