Abstract Cytochrome P450 (CYP) induction-mediated interaction is one of the major
concerns in clinical practice and for the pharmaceutical industry. There are two major issues …

Tetraspanins (Tspans) are a family of four-span transmembrane proteins, known as plasma
membrane “master organizers.” They form Tspan-enriched microdomains (TEMs or TERMs) …

Introduction:'Orphan'nuclear receptors belong to the nuclear receptor (NR) superfamily of
transcriptional factors. Binding of ligands to these receptors results in the recruitment of the …

Pregnane X receptor (PXR, NR1I2) and constitutive androstane receptor (CAR, NR1I3) are
members of the nuclear receptor superfamily that mainly act as ligand-activated transcription …

In this minireview, the role of various nuclear receptors and transcription factors in the
expression of drug disposition genes is summarized. Specifically, the molecular aspects and …

Two nuclear receptors, the pregnane X receptor (PXR) and the constitutive androstane
receptor (CAR), participate in the xenobiotic detoxification system by regulating the …

Mouse nongenotoxic hepatocarcinogens phenobarbital (PB) and chlordane induce
hepatomegaly characterized by hypertrophy and hyperplasia. Increased cell proliferation is …

The defense mechanisms responsible for protecting the body from endogenous toxins are
also involved in the metabolism of drugs and are composed of phase I and phase II drug …

Xenobiotic metabolism and detoxification is regulated by receptors (eg, PXR, CAR) whose
characterization has contributed significantly to our understanding of drug responses in …

Abstract Objectives Cytochrome P450 2B6 (CYP2B6) is responsible for the metabolic
clearance of efavirenz and single nucleotide polymorphisms (SNPs) in the CYP2B6 gene …