Failed proteostasis is a well-documented feature of Alzheimer's disease, particularly,
reduced protein degradation and clearance. However, the contribution of failed proteostasis …

Digital biomarkers that remotely monitor symptoms have the potential to revolutionize
outcome assessments in future disease-modifying trials in Parkinson's disease (PD), by …

The aging population and the prevalence of infectious diseases have impacted the
traditional medical order, significantly increasing the burden on healthcare and adversely …

Psychiatry is rapidly adopting digital phenotyping and artificial intelligence/machine learning
tools to study mental illness based on tracking participants' locations, online activity, phone …

Background One of the most pressing issues in our society is the provision of proper care
and treatment for the growing global health challenge of ageing. Assistive Technology and …

Heart rate response to physical activity is widely investigated in clinical and training practice,
as it provides information on a person's physical state. For emerging digital phenotyping …

In the medical field, there are several very different movement disorders, such as tremors,
Parkinson's disease, or Huntington's disease. A wide range of motor and non-motor …

Pain and frailty are closely linked. Chronic pain is a risk factor for frailty, and frailty is a risk
factor for pain. People living with frailty also commonly have cognitive impairment, which can …

The results of many epidemiological studies suggest a bidirectional causality may exist
between epilepsy and Parkinson's disease (PD). However, the underlying molecular …

Background Age-friendly environments intend to promote active ageing by facilitating social,
mental, and physical participation. This could potentially delay the onset of chronic complex …