Epigenetic inheritance and the missing heritability
Genome-wide association studies of complex physiological traits and diseases consistently
found that associated genetic factors, such as allelic polymorphisms or DNA mutations, only …
found that associated genetic factors, such as allelic polymorphisms or DNA mutations, only …
The role of epigenetics in placental development and the etiology of preeclampsia
C Apicella, CSM Ruano, C Méhats, F Miralles… - International journal of …, 2019 - mdpi.com
In this review, we comprehensively present the function of epigenetic regulations in normal
placental development as well as in a prominent disease of placental origin, preeclampsia …
placental development as well as in a prominent disease of placental origin, preeclampsia …
Unsupervised clustering and epigenetic classification of single cells
Characterizing epigenetic heterogeneity at the cellular level is a critical problem in the
modern genomics era. Assays such as single cell ATAC-seq (scATAC-seq) offer an …
modern genomics era. Assays such as single cell ATAC-seq (scATAC-seq) offer an …
[HTML][HTML] ESCs require PRC2 to direct the successful reprogramming of differentiated cells toward pluripotency
Embryonic stem cells (ESCs) are pluripotent, self-renewing, and have the ability to
reprogram differentiated cell types to pluripotency upon cellular fusion. Polycomb-group …
reprogram differentiated cell types to pluripotency upon cellular fusion. Polycomb-group …
Human placental cytotrophoblast epigenome dynamics over gestation and alterations in placental disease
The human placenta and its specialized cytotrophoblasts rapidly develop, have a
compressed lifespan, govern pregnancy outcomes, and program the offspring's health …
compressed lifespan, govern pregnancy outcomes, and program the offspring's health …
Epigenetic mechanisms of endothelial dysfunction in type 2 diabetes
The development of type-2 diabetes mellitus (T2DM) and its complications is largely due to
the complex interaction between genetic factors and environmental influences, mainly …
the complex interaction between genetic factors and environmental influences, mainly …
[HTML][HTML] Adaptive mechanisms controlling uterine spiral artery remodeling during the establishment of pregnancy
MJ Soares, D Chakraborty, K Kubota… - The International …, 2014 - ncbi.nlm.nih.gov
Implantation of the embryo into the uterus triggers the initiation of hemochorial placentation.
The hemochorial placenta facilitates the acquisition of maternal resources required for …
The hemochorial placenta facilitates the acquisition of maternal resources required for …
Transition of inner cell mass to embryonic stem cells: mechanisms, facts, and hypotheses
Embryonic stem cells (ESCs) are immortal stem cells that own multi-lineage differentiation
potential. ESCs are commonly derived from the inner cell mass (ICM) of pre-implantation …
potential. ESCs are commonly derived from the inner cell mass (ICM) of pre-implantation …
SATB homeobox proteins regulate trophoblast stem cell renewal and differentiation
K Asanoma, K Kubota, D Chakraborty… - Journal of Biological …, 2012 - ASBMB
The morphogenesis of the hemochorial placenta is dependent upon the precise expansion
and differentiation of trophoblast stem (TS) cells. SATB homeobox 1 (SATB1) and SATB2 …
and differentiation of trophoblast stem (TS) cells. SATB homeobox 1 (SATB1) and SATB2 …
The role of telomere-binding modulators in pluripotent stem cells
Pluripotent stem cells (PSCs) such as embryonic stem cells (ESCs), ESCs derived by
somatic cell nuclear transfer (ntESCs), and induced pluripotent stem cells (iPSCs) have …
somatic cell nuclear transfer (ntESCs), and induced pluripotent stem cells (iPSCs) have …