New antimalarial targets are the prime need for the discovery of potent drug candidates. In
order to fulfill this objective, antimalarial drug researches are focusing on promising targets …

Isoprenoid biosynthesis is essential for cell survival. Over 35 000 isoprenoid molecules have
been identified to date in the three domains of life (bacteria, archaea and eukaryotes), and …

Decaprenyl‐phospho‐arabinose (β‐d‐arabinofuranosyl‐1‐O‐monophosphodecaprenol),
the only known donor of d‐arabinose in bacteria, and its precursor, decaprenyl‐phospho …

A short history of hybrid molecules based on aminoquinolines gave interesting and
important information useful for organic and medicinal chemistry, which are deeply involved …

To address the continued rise of multi-drug-resistant microorganisms, the development of
novel drugs with new modes of action is urgently required. While humans biosynthesize the …

The 2-C-methyl-D-erythritol-4-phosphate (MEP) pathway for isoprenoid biosynthesis has
come under increased scrutiny as a target for novel antimalarial, antibacterial and herbicidal …

The human malaria parasite Plasmodium falciparum is responsible for the deaths of more
than a million people each year. Fosmidomycin has been proven to be efficient in the …

The doom and gloom of antibiotic resistance dominates public perception of this drug class.
Many believe the world has entered the post-antibiotic era. Classic and modern approaches …

The biological activity and natural occurrence of the aminophosphonic acids were described
half a century ago. Since then the chemistry and biology of this class of compounds have …

Isoprenoids, a diverse class of natural products, are present in all living organisms. Their two
universal building blocks are synthesized via two independent pathways: the mevalonate …