Clinical trials of nicotine vaccines suggest that they can enhance smoking cessation rates
but do not reliably produce the consistently high serum antibody concentrations required. A …

Biologics (vaccines, monoclonal antibodies (mAb), and genetically modified enzymes) offer
a promising class of therapeutics to treat substance use disorders (SUD) involving abuse of …

Poorly immunogenic small molecules pose challenges for the production of clinically
efficacious vaccines and antibodies. To address this, we generate an immunization platform …

Abstract Background and Aims Nicotine vaccination has been proposed as a possible
treatment to aid smoking cessation. First efficacy results of the nicotine vaccine 3′‐AmNic …

Opioid use disorder (OUD) has become a public health crisis, with recent significant
increases in the number of deaths due to overdose. Vaccination can provide an attractive …

Introduction: Cocaine use is a global public health concern of significant magnitude,
negatively impacting both the individual as well as larger society. Despite numerous trials …

The prevalence and societal impact of opioid use disorder (OUD) is an acknowledged public
health crisis that is further aggravated by the current pandemic. One of the devastating …

Active vaccination is an effective therapeutic option to reduce the reinforcing effects of
opioids. Several studies showed that chronic stress affects the immune system decreasing …

A leading nicotine conjugate vaccine was only efficacious for one-third of clinical trial
participants, likely due in part to its use of racemic nicotine hapten,(±)-3′-AmNic …

Betel-quid chewing addiction is the leading cause of oral submucous fibrosis and oral
cancer, resulting in significant socio-economic burdens. Vaccination may serve as a …