Pathways and disease-causing alterations in visual chromophore production for vertebrate vision

PD Kiser, K Palczewski - Journal of Biological Chemistry, 2021 - ASBMB
All that we view of the world begins with an ultrafast cis to trans photoisomerization of the
retinylidene chromophore associated with the visual pigments of rod and cone …

The molecular aspects of absorption and metabolism of carotenoids and retinoids in vertebrates

MAK Widjaja-Adhi, M Golczak - … et Biophysica Acta (BBA)-Molecular and …, 2020 - Elsevier
Vitamin A is an essential nutrient necessary for numerous basic physiological functions,
including reproduction and development, immune cell differentiation and communication, as …

Molecular components affecting ocular carotenoid and retinoid homeostasis

J von Lintig, J Moon, D Babino - Progress in retinal and eye research, 2021 - Elsevier
The photochemistry of vision employs opsins and geometric isomerization of their covalently
bound retinylidine chromophores. In different animal classes, these light receptors associate …

[HTML][HTML] Deficiency in Acyl-CoA: Wax Alcohol Acyltransferase 2 causes evaporative dry eye disease by abolishing biosynthesis of wax esters

MAK Widjaja-Adhi, JA Silvaroli… - … : official publication of …, 2020 - ncbi.nlm.nih.gov
Lipids secreted by the meibomian glands (MGs) of the eyelids are essential to the protection
of the eye's surface. An altered meibum composition represents the primary cause of …

[HTML][HTML] Conditional deletion of Des1 in the mouse retina does not impair the visual cycle in cones

PD Kiser, AV Kolesnikov, JZ Kiser, Z Dong… - The FASEB …, 2019 - ncbi.nlm.nih.gov
Cone photoreceptors are essential for vision under moderate to high illuminance and allow
color discrimination. Their fast dark adaptation rate and resistance to saturation are believed …

Abnormal cannabidiol modulates vitamin A metabolism by acting as a competitive inhibitor of CRBP1

JA Silvaroli, MAK Widjaja-Adhi, T Trischman… - ACS chemical …, 2019 - ACS Publications
Cellular retinol-binding proteins (CRBPs) facilitate the uptake and intracellular transport of
vitamin A. They integrate retinoid metabolism, playing an important role in regulating the …

Genetic variations of vitamin A-absorption and storage-Related genes, and their potential contribution to vitamin A deficiency risks among different ethnic groups

M Suzuki, M Tomita - Frontiers in Nutrition, 2022 - frontiersin.org
Vitamin A, an essential fat-soluble micronutrient, plays a critical role in the body, by
regulating vision, immune responses, and normal development, for instance. Vitamin A …

Evolutionary and biochemical characterization of a Chromochloris zofingiensis MBOAT with wax synthase and diacylglycerol acyltransferase activity

Y Xu, X Pan, J Lu, J Wang, Q Shan… - Journal of …, 2021 - academic.oup.com
Wax synthase (WS) catalyzes the last step in wax ester biosynthesis in green plants. Two
unrelated sub-families of WS, including the bifunctional acyltransferase and plant-like WS …

[HTML][HTML] Acyl-CoA: wax alcohol acyltransferase 2 modulates the cone visual cycle in mouse retina

MAK Widjaja-Adhi, AV Kolesnikov… - … : official publication of …, 2022 - ncbi.nlm.nih.gov
The daylight and color vision of diurnal vertebrates depends on cone photoreceptors. The
capability of cones to operate and respond to changes in light brightness even under high …

The transcription factor IRF-5 is essential for the metabolic rewiring of CD8 T cells during chronic infection

LT Mai, S Swaminathan, TH Nguyen, T Charpentier… - bioRxiv, 2024 - biorxiv.org
Numerous transcription factors are involved in promoting an intricate gene expression
program that leads to CD8 T cell exhaustion. Here, we found that the transcription factor IRF …