Abstract α‐Thalassemia represents one of the most important genetic modulators of β‐
hemoglobinopathies. During this last decade, the ongoing interest in characterizing …

When adding peroxide (H 2 O 2), β subunits of hemoglobin (Hb) bear the burden of
oxidative changes due in part to the direct oxidation of its Cys93. The presence of unpaired …

Clinical severity assessment and molecular analysis of β-, α-globin genes and the− 158 (C>
T) Xmn I polymorphism of the Gγ-globin gene were performed in 80 pediatric patients with …

Background Excessive expression of hemoglobin F (HbF) is a characteristic feature and
important diagnostic marker of β 0-thalassemia/HbE disease. However, some patients may …

Thalassemia is the most common inherited hemoglobinopathy worldwide. Variation of
clinical symptoms in this hemoglobinopathy entails differences in disease-onset and …

Abstract Hb E [β26 (B8) Glu→ Lys; HBB: c. 79G> A]-β-thalassemia (β-thal) has an extremely
variable clinical presentation. We report the clinical features of these patients from five …

This chapter reports the essential elements needed to understand basic laboratory
diagnostics consisting of separation and measurement of the hemoglobin fractions …

Background: α-thalassemia, resulting largely from deletions in the α-globin chain of
hemoglobin, is one of the most common inherited blood disorders among the Asian …

Thalassemia is a common monogenic autosomal disorder prevalent in India. HbE beta
thalassemia is a compound heterozygous state of two different beta globin mutations (HBB) …

The thalassaemias are the most common monogenic disorders worldwide. Both α-and β-
thalassaemia are caused by genetic mutations that result in a decrease in globin gene …