Despite advances in neurosurgical techniques and radio-/chemotherapy, the treatment of
brain tumors remains a challenge. This is particularly true for the most frequent and fatal …

Macroautophagy (autophagy herein) is a cellular stress response and a survival pathway
that is responsible for the degradation of long-lived proteins, protein aggregates, as well as …

Glioblastoma (GBM) consists of a heterogeneous collection of competing cellular clones
which communicate with each other and with the tumor microenvironment (TME) …

Non-coding RNAs (ncRNAs) have been implicated in most cellular functions. The disruption
of their function through somatic mutations, genomic imprinting, transcriptional and post …

Autophagy is a cellular stress response mechanism activation of which leads to degradation
of cellular components, including proteins as well as damaged organelles in lysosomes …

Innate and acquired chemoresistance exhibited by most tumours exposed to conventional
chemotherapeutic agents account for the majority of relapse cases in cancer patients. Such …

Chemo-resistance, which is the main obstacle in cancer therapy, is caused by the onset of
drug-resistant cells in the heterogeneous cell population in cancer tissues. MicroRNAs …

The role of microRNA in the aberrant autophagy that occurs in pancreatic cancer remains
controversial. Because hypoxia is known to induce autophagy, we screened for differentially …

Induction of lethal autophagy has become a strategy to eliminate glioma cells, but it remains
elusive whether autophagy contributes to cell death via causing mitochondria damage and …

Temozolomide (TMZ) is one of the most common drugs selected for glioma chemotherapy,
but the therapeutic effect of glioma treatment is usually limited due to its resistance. Long …