Crossing the blood-brain barrier: advances in nanoparticle technology for drug delivery in neuro-oncology

AM Hersh, S Alomari, BM Tyler - International journal of molecular …, 2022 - mdpi.com
The blood-brain barrier (BBB) constitutes a microvascular network responsible for excluding
most drugs from the brain. Treatment of brain tumors is limited by the impermeability of the …

Boron neutron capture therapy: Current status and future perspectives

MA Dymova, SY Taskaev, VA Richter… - Cancer …, 2020 - Wiley Online Library
The development of new accelerators has given a new impetus to the development of new
drugs and treatment technologies using boron neutron capture therapy (BNCT). We …

Transcytosis to cross the blood brain barrier, new advancements and challenges

VM Pulgar - Frontiers in neuroscience, 2019 - frontiersin.org
The blood brain barrier (BBB) presents a formidable challenge to the delivery of drugs into
the brain. Several strategies aim to overcome this obstacle and promote efficient and …

Targeting the transferrin receptor for brain drug delivery

KB Johnsen, A Burkhart, LB Thomsen… - Progress in …, 2019 - Elsevier
Obtaining efficient drug delivery to the brain remains the biggest challenge for the
development of therapeutics to treat diseases of the central nervous system. The main …

pH-sensitive biomaterials for drug delivery

S Zhuo, F Zhang, J Yu, X Zhang, G Yang, X Liu - Molecules, 2020 - mdpi.com
The development of precise and personalized medicine requires novel formulation
strategies to deliver the therapeutic payloads to the pathological tissues, producing …

Liposomal delivery systems: design optimization and current applications

ASA Lila, T Ishida - Biological and pharmaceutical bulletin, 2017 - jstage.jst.go.jp
The liposome, a closed phospholipid bilayered vesicular system, has received considerable
attention as a pharmaceutical carrier of great potential over the past 30 years. The ability of …

Advances in liposomal drug delivery to cancer: An overview

S Saraf, A Jain, A Tiwari, A Verma, PK Panda… - Journal of drug delivery …, 2020 - Elsevier
Liposomes are biodegradable and biocompatible lipid bilayer vesicles which are widely
exploited as preferred carriers for smart delivery of both hydrophobic as well as hydrophilic …

Nanoparticle-based drug delivery systems targeting cancer cell surfaces

L Hong, W Li, Y Li, S Yin - RSC advances, 2023 - pubs.rsc.org
Traditional cancer chemotherapy easily produces serious toxic and side effects due to the
lack of specific selection of tumor cells, which restricts its curative effect. Targeted delivery …

Vitamin E TPGS-based nanomedicine, nanotheranostics, and targeted drug delivery: past, present, and future

AK Mehata, A Setia, AK Malik, R Hassani, HG Dailah… - Pharmaceutics, 2023 - mdpi.com
It has been seventy years since a water-soluble version of vitamin E called tocophersolan
(also known as TPGS) was produced; it was approved by USFDA in 1998 as an inactive …

Nanotechnology in drug and gene delivery

S Hamimed, M Jabberi, A Chatti - Naunyn-schmiedeberg's Archives of …, 2022 - Springer
Over the last decade, nanotechnology has widely addressed many nanomaterials in the
biomedical area with an opportunity to achieve better-targeted delivery, effective treatment …