Towards more accurate bioimaging of drug nanocarriers: turning aggregation-caused quenching into a useful tool

J Qi, X Hu, X Dong, Y Lu, H Lu, W Zhao… - Advanced Drug Delivery …, 2019 - Elsevier
One of the current challenges in the monitoring of drug nanocarriers lies in the difficulties in
discriminating the carrier-bound signals from the bulk signals of probes. Environment …

Systematic review of targeted extracellular vesicles for drug delivery–considerations on methodological and biological heterogeneity

JM Gudbergsson, K Jønsson, JB Simonsen… - Journal of Controlled …, 2019 - Elsevier
The idea of using extracellular vesicles (EVs) for targeted drug delivery was first introduced
in 2011 and has since then gained increasing attention as promising new candidates in the …

Nucleic acid delivery with extracellular vesicles

M Schulz-Siegmund, A Aigner - Advanced drug delivery reviews, 2021 - Elsevier
Extracellular vesicles (EVs) are membrane-enclosed particles, heterogeneous in size,
shape, contents, biogenesis and structure. They are released by eukaryotic and prokaryotic …

Microbe-host communication by small RNAs in extracellular vesicles: vehicles for transkingdom RNA transportation

HJ Lee - International journal of molecular sciences, 2019 - mdpi.com
Extracellular vesicles (EVs) are evolutionary well-conserved nano-sized membranous
vesicles that are secreted by both prokaryotic and eukaryotic cells. Recently, they have …

Optimized cholesterol-siRNA chemistry improves productive loading onto extracellular vesicles

RA Haraszti, R Miller, MC Didiot, A Biscans… - Molecular Therapy, 2018 - cell.com
Extracellular vesicles are promising delivery vesicles for therapeutic RNAs. Small interfering
RNA (siRNA) conjugation to cholesterol enables efficient and reproducible loading of …

Microfluidic size exclusion chromatography (μSEC) for extracellular vesicles and plasma protein separation

SY Leong, HB Ong, HM Tay, F Kong, M Upadya… - Small, 2022 - Wiley Online Library
Extracellular vesicles (EVs) are recognized as next generation diagnostic biomarkers due to
their disease‐specific biomolecular cargoes and importance in cell–cell communications. A …

Improved label-free identification of individual exosome-like vesicles with Au@ Ag nanoparticles as SERS substrate

JC Fraire, S Stremersch, D Bouckaert… - … applied materials & …, 2019 - ACS Publications
Exosome-like vesicles (ELVs) are nanovectors released by cells that are endowed with a
variety of molecules, including proteins, nucleic acids, and chemicals that reflect the …

Extracellular vesicle-derived miRNA as a novel regulatory system for bi-directional communication in gut-brain-microbiota axis

L Zhao, Y Ye, L Gu, Z Jian, CM Stary… - Journal of Translational …, 2021 - Springer
The gut-brain-microbiota axis (GBMAx) coordinates bidirectional communication between
the gut and brain, and is increasingly recognized as playing a central role in physiology and …

Exosome and macrophage crosstalk in sleep-disordered breathing-induced metabolic dysfunction

A Khalyfa, L Kheirandish-Gozal, D Gozal - International Journal of …, 2018 - mdpi.com
Obstructive sleep apnea (OSA) is a highly prevalent worldwide public health problem that is
characterized by repetitive upper airway collapse leading to intermittent hypoxia …

Converging multidimensional sensor and machine learning toward high-throughput and biorecognition element-free multidetermination of extracellular vesicle …

CYN Nicoliche, RAG de Oliveira, GS da Silva… - ACS …, 2020 - ACS Publications
Extracellular vesicles (EVs) are a frontier class of circulating biomarkers for the diagnosis
and prognosis of different diseases. These lipid structures afford various biomarkers such as …