The formation of new blood vessels, or angiogenesis, is a complex process that plays
important roles in growth and development, tissue and organ regeneration, as well as …

Decades of research have disclosed a plethora of alterations in protein glycosylation that
decisively impact in all stages of disease and ultimately contribute to more aggressive cell …

The majority of ovarian cancer patients present with advanced disease and despite
aggressive treatment, prognosis remains poor. Significant improvement in ovarian cancer …

Inositol-requiring enzyme 1 (IRE1) is a proximal endoplasmic reticulum (ER) stress sensor
and a central mediator of the unfolded protein response. In a human glioma model …

Background Gliomas exhibit high glycolytic rates, and monocarboxylate transporters (MCTs)
play a major role in the maintenance of the glycolytic metabolism through the proton-linked …

Among the in vivo models, the chick embryo chorioallantoic membrane (CAM) has been
used to implant several tumor types as well as malignant cell lines to study their growth rate …

Simple Summary The chorioallantoic membrane (CAM) model is an alternative in vivo test
system for the study of hallmarks of cancer such as angiogenesis, tumor growth, immune …

Patient-derived xenografts (PDX) are an increasingly valuable tool in oncology, providing
biologically faithful models of many different cancer types, and potential platforms for the …

The ability of carcinoma cells arising at primary sites to cross their underlying basement
membrane (BM), a specialized form of extracellular matrix that subtends all epithelial cells …

In solid tumors, cancer cells subjected to ischemic conditions trigger distinct signaling
pathways contributing to angiogenic stimulation and tumor development. Characteristic …