Near-infrared spectroscopy (NIRS) measurements of cytochrome-c-oxidase (CCO) have the
potential to yield crucial information about cerebral metabolism at the patient bedside …

The blooming of neonatal neurocritical care over the last decade reflects substantial
advances in neuromonitoring and neuroprotection. The most commonly used brain …

Background: Neonatal hypoxic ischemic encephalopathy (HIE) remains a significant cause
of mortality and morbidity worldwide. Cerebral near infrared spectroscopy (NIRS) can …

Background Current diagnostic criteria for hypoxic–ischemic encephalopathy in the early
hours lack objective measurement tools. Therefore, this systematic review aims to identify …

There is a need for a method of real-time assessment of brain metabolism during neonatal
hypoxic-ischaemic encephalopathy (HIE). We have used broadband near-infrared …

Perinatal hypoxia-ischemia (HI) is still a significant contributor to mortality and adverse
neurodevelopmental outcomes in term and preterm infants. HI brain injury evolves over …

Neonatal encephalopathy (NE) in term and near-term infants is a significant global health
problem; the worldwide burden of disease remains high despite the introduction of …

Hypoxic ischemic encephalopathy (HIE) leads to significant morbidity and mortality.
Impaired autoregulation after hypoxia-ischaemia has been suggested to contribute further to …

Extremely preterm infants are at higher risk of pulmonary (PH) and intraventricular (IVH)
haemorrhage during the transitioning physiology due to immature cardiovascular system …

Background Opportunities for adjunct therapies with cooling in neonatal encephalopathy are
imminent; however, robust biomarkers of early assessment are lacking. Using an optical …