The accumulation of amyloid-β-containing neuritic plaques and intracellular tau protein
tangles are key histopathological hallmarks of Alzheimer's disease (AD). This type of …

Autophagy is best known for its role in organelle and protein turnover, cell quality control,
and metabolism. The autophagic machinery has, however, also adapted to enable protein …

Autophagy is a catabolic process that degrades cytoplasmic constituents and organelles in
the lysosome, thus serving an important role in cellular homeostasis and protection against …

Enteroviruses are non-enveloped positive-sense RNA viruses that cause diverse diseases
in humans. Their rapid multiplication depends on remodeling of cytoplasmic membranes for …

Since the severe acute respiratory syndrome (SARS) outbreak in 2003, human
coronaviruses (hCoVs) have been identified as causative agents of severe acute respiratory …

The Beclin family, including yeast Atg6 (autophagy related gene 6), its orthologs in higher
eukaryotic species, and the more recently characterized mammalian-specific Beclin 2, are …

Autophagy is a constitutive cellular process of degradation required to maintain homeostasis
and turn over spent organelles and aggregated proteins. For some viruses, the process can …

Foot-and-mouth disease (FMD) is a highly contagious disease of cloven-hoofed animals,
which has been regarded as a persistent challenge for the livestock industry in many …

Foot-and-mouth disease virus (FMDV) represses host translation machinery, blocks protein
secretion, and cleaves cellular proteins associated with signal transduction and the innate …

Autophagy is a cell 'self-digestion'pathway involving the synthesis, trafficking and delivery of
autophagosomes to lysosomes for degradation. Beclin 1 (encoded by BECN1) is a core …