Drug Resistance in Toxoplasma gondii

M Montazeri, S Mehrzadi, M Sharif, S Sarvi… - Frontiers in …, 2018 - frontiersin.org
Toxoplasma gondii (T. gondii) is a global protozoan parasite infecting up to one-third of the
world population. Pyrimethamine (PYR) and sulfadiazine (SDZ) are the most widely used …

Human toxoplasmosis–Searching for novel chemotherapeutics

M Antczak, K Dzitko, H Długońska - Biomedicine & Pharmacotherapy, 2016 - Elsevier
The protozoan Toxoplasma gondii, an obligate intracellular parasite, is an etiological agent
of human and animal toxoplasmosis. Treatment regimens for T. gondii-infected patients …

Toxoplasmosis: Current and emerging parasite druggable targets

RE Hajj, L Tawk, S Itani, M Hamie, J Ezzeddine… - Microorganisms, 2021 - mdpi.com
Toxoplasmosis is a prevalent disease affecting a wide range of hosts including
approximately one-third of the human population. It is caused by the sporozoan parasite …

Promising Drug Targets and Compounds with Anti-Toxoplasma gondii Activity

M Silva, C Teixeira, P Gomes, M Borges - Microorganisms, 2021 - mdpi.com
Toxoplasmosis is a parasitic disease caused by the globally distributed protozoan parasite
Toxoplasma gondii, which infects around one-third of the world population. This disease …

Discovery of new inhibitors of Toxoplasma gondii via the pathogen box

J Spalenka, S Escotte-Binet, A Bakiri… - Antimicrobial agents …, 2018 - Am Soc Microbiol
Toxoplasma gondii is a cosmopolitan protozoan parasite which affects approximately 30%
of the population worldwide. The drugs currently used against toxoplasmosis are few in …

[HTML][HTML] Sulfadiazine resistance in Toxoplasma gondii: no involvement of overexpression or polymorphisms in genes of therapeutic targets and ABC transporters

C Doliwa, S Escotte-Binet, D Aubert, V Sauvage… - Parasite, 2013 - ncbi.nlm.nih.gov
Several treatment failures have been reported for the treatment of toxoplasmic encephalitis,
chorioretinitis, and congenital toxoplasmosis. Recently we found three Toxoplasma gondii …

Efficacy of sulfadiazine and pyrimetamine for treatment of experimental toxoplasmosis with strains obtained from human cases of congenital disease in Brazil

LA Silva, MD Fernandes, AS Machado… - Experimental …, 2019 - Elsevier
Abstract Toxoplasmosis in South America presents great health impacts and is a topic of
research interest not only because of the severity of native cases but also due to the …

[HTML][HTML] Anti-Toxoplasma gondii effect of lupane-type triterpenes from the bark of black alder (Alnus glutinosa) and identification of a potential target by reverse …

P Darme, S Escotte-Binet, J Cordonnier, S Remy… - Parasite, 2022 - ncbi.nlm.nih.gov
Toxoplasmosis is a worldwide parasitosis that is generally benign. The infestation may pose
a risk to immunocompromized patients and to fetuses when pregnant women have recently …

Isolation and characterization of antiprotozoal compound-producing Streptomyces species from Mongolian soils

B Pagmadulam, D Tserendulam, T Rentsenkhand… - Parasitology …, 2020 - Elsevier
Natural resources are recognized as important sources of potential drugs for treating various
infections, and microorganisms are a rich natural source of diverse compounds. Among the …

Investigation of Antiparasitic Activity of 10 European Tree Bark Extracts on Toxoplasma gondii and Bioguided Identification of Triterpenes in Alnus glutinosa Barks

P Darme, J Spalenka, J Hubert… - Antimicrobial Agents …, 2022 - Am Soc Microbiol
Toxoplasmosis is a worldwide parasitosis that affects one-third of the population. People at
risk, such as immunocompromised patients (AIDS, chemotherapy treatment) or fetuses …