Recent advancements of coumarin-based anticancer agents: An up-to-date review
Heading the list of the critical health-related issues worldwide, cancer continues to be a one
of the most serious life-threatening diseases. The rate of cancer-related mortality is at …
of the most serious life-threatening diseases. The rate of cancer-related mortality is at …
Trending topics on coumarin and its derivatives in 2020
Coumarins are naturally occurring molecules with a versatile range of activities. Their
structural and physicochemical characteristics make them a privileged scaffold in medicinal …
structural and physicochemical characteristics make them a privileged scaffold in medicinal …
Targeting carbonic anhydrase IX and XII isoforms with small molecule inhibitors and monoclonal antibodies
Carbonic anhydrases IX and CAXII (CAIX/CAXII) are transmembrane zinc metalloproteins
that catalyze a very basic but crucial physiological reaction: the conversion of carbon dioxide …
that catalyze a very basic but crucial physiological reaction: the conversion of carbon dioxide …
A decade of tail-approach based design of selective as well as potent tumor associated carbonic anhydrase inhibitors
Human carbonic anhydrase (hCA) isoforms hCA IX and hCA XII are well established
anticancer drug targets and their selective inhibition is highly desired for the proper …
anticancer drug targets and their selective inhibition is highly desired for the proper …
Research progress on the synthesis and pharmacology of 1, 3, 4-oxadiazole and 1, 2, 4-oxadiazole derivatives: a mini review
JJ Wang, W Sun, WD Jia, M Bian… - Journal of Enzyme …, 2022 - Taylor & Francis
Oxadiazole is a five-membered heterocyclic compound containing two nitrogen atoms and
one oxygen atom. The 1, 3, 4-oxadiazole and 1, 2, 4-oxadiazole have favourable physical …
one oxygen atom. The 1, 3, 4-oxadiazole and 1, 2, 4-oxadiazole have favourable physical …
Carbonic anhydrases: Versatile and useful biocatalysts in chemistry and biochemistry
Metalloenzymes such as the carbonic anhydrases (CAs, EC 4.2. 1.1) possess highly
specialized active sites that promote fast reaction rates and high substrate selectivity for the …
specialized active sites that promote fast reaction rates and high substrate selectivity for the …
Room temperature synthesis of bioactive 1, 2, 4-oxadiazoles
1, 2, 4-Oxadiazole is an essential motif in drug discovery represented in many experimental,
investigational, and marketed drugs. This review covers synthetic methods that allow the …
investigational, and marketed drugs. This review covers synthetic methods that allow the …
Design, synthesis and mechanism study of coumarin-sulfonamide derivatives as carbonic anhydrase IX inhibitors with anticancer activity
Q Lv, J Zhang, J Cai, L Chen, J Liang, T Zhang… - Chemico-Biological …, 2024 - Elsevier
In this study, twenty-nine coumarin-3-sulfonamide derivatives, twenty-seven of which are
original were designed and synthesized. Cytotoxicity assay indicated that most of these …
original were designed and synthesized. Cytotoxicity assay indicated that most of these …
Synthesis and biological evaluation of some coumarin hybrids as selective carbonic anhydrase IX and XII inhibitors
PS Thacker, NS Goud, OS Argulwar, J Soman… - Bioorganic …, 2020 - Elsevier
Two series, coumarin-linked to thiazolidinone via a pyrazole linker (6a-m, Series 1) and
coumarin-linked 1, 2, 3-triazoles (5a-j, Series 2) were synthesized and the synthesized …
coumarin-linked 1, 2, 3-triazoles (5a-j, Series 2) were synthesized and the synthesized …
[HTML][HTML] Therapeutic potential of 4-substituted coumarins: A conspectus
Substituted coumarins are a very large family of naturally occurring compounds, and
substituted coumarins are versatile scaffolds for the development of medicinally active …
substituted coumarins are versatile scaffolds for the development of medicinally active …