Gut-innervating nociceptors regulate the intestinal microbiota to promote tissue protection
Nociceptive pain is a hallmark of many chronic inflammatory conditions including
inflammatory bowel diseases (IBDs); however, whether pain-sensing neurons influence …
inflammatory bowel diseases (IBDs); however, whether pain-sensing neurons influence …
Challenges and opportunities in translational pain research–An opinion paper of the working group on translational pain research of the European pain federation …
For decades, basic research on the underlying mechanisms of nociception has held promise
to translate into efficacious treatments for patients with pain. Despite great improvement in …
to translate into efficacious treatments for patients with pain. Despite great improvement in …
[HTML][HTML] DRG afferents that mediate physiologic and pathologic mechanosensation from the distal colon
RL Wolfson, A Abdelaziz, G Rankin, S Kushner, L Qi… - Cell, 2023 - cell.com
The properties of dorsal root ganglia (DRG) neurons that innervate the distal colon are
poorly defined, hindering our understanding of their roles in normal physiology and …
poorly defined, hindering our understanding of their roles in normal physiology and …
A brief review of in vitro models for injury and regeneration in the peripheral nervous system
P Varier, G Raju, P Madhusudanan, C Jerard… - International Journal of …, 2022 - mdpi.com
Nerve axonal injury and associated cellular mechanisms leading to peripheral nerve
damage are important topics of research necessary for reducing disability and enhancing …
damage are important topics of research necessary for reducing disability and enhancing …
Multifunctional Nanomesh Enables Cellular‐Resolution, Elastic Neuroelectronics
Silicone‐based devices have the potential to achieve an ideal interface with nervous tissue
but suffer from scalability, primarily due to the mechanical mismatch between established …
but suffer from scalability, primarily due to the mechanical mismatch between established …
BzATP activates satellite glial cells and increases the excitability of dorsal root ganglia neurons in vivo
The purinergic system plays an important role in pain transmission. Recent studies have
suggested that activation of P2-purinergic receptors (P2Rs) may be involved in neuron …
suggested that activation of P2-purinergic receptors (P2Rs) may be involved in neuron …
Calcium imaging in population of dorsal root ganglion neurons unravels novel mechanisms of visceral pain sensitization and referred somatic hypersensitivity
Mechanisms of visceral pain sensitization and referred somatic hypersensitivity remain
unclear. We conducted calcium imaging in Pirt-GCaMP6s mice to gauge responses of …
unclear. We conducted calcium imaging in Pirt-GCaMP6s mice to gauge responses of …
Sex differences in zymosan-induced behavioral visceral hypersensitivity and colorectal afferent sensitization
Sex differences in visceral nociception have been reported in clinical and preclinical studies,
but the potential differences in sensory neural encoding of the colorectum between males …
but the potential differences in sensory neural encoding of the colorectum between males …
Load-bearing function of the colorectal submucosa and its relevance to visceral nociception elicited by mechanical stretch
Mechanical distension beyond a particular threshold evokes visceral pain from distal colon
and rectum (colorectum), and thus biomechanics plays a central role in visceral nociception …
and rectum (colorectum), and thus biomechanics plays a central role in visceral nociception …
Morphological, molecular, and functional characterization of mouse glutamatergic myenteric neurons
The enteric nervous system (ENS) functions largely independently of the central nervous
system (CNS). Glutamate, the dominant neurotransmitter in the CNS and sensory afferents …
system (CNS). Glutamate, the dominant neurotransmitter in the CNS and sensory afferents …