Ca2+-release channels are giant membrane proteins that control the release of Ca2+ from
the endoplasmic and sarcoplasmic reticulum. The two members, ryanodine receptors …

Ca2+ is a fundamental second messenger in all cell types and is required for numerous
essential cellular functions, including cardiac and skeletal muscle contraction. The …

Large-conductance Ca2+ release channels known as ryanodine receptors (RyRs) mediate
the release of Ca2+ from an intracellular membrane compartment, the endo/sarcoplasmic …

Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a devastating inherited
disorder characterized by episodic syncope and/or sudden cardiac arrest during exercise or …

The high-conductance intracellular calcium (Ca2+) channel RyR2 is essential for the
coupling of excitation and contraction in cardiac muscle. Among various modulators …

Among the most intriguing forms of Ca 2+ channel modulation is the regulation of L-type and
P/Q-type channels by intracellular Ca 2+, acting via unconventional channel-calmodulin …

Calcium (Ca2+) is a ubiquitous intracellular messenger, controlling a diverse range of
cellular processes, such as gene transcription, muscle contraction and cell proliferation. The …

Inositol 1, 4, 5-trisphosphate receptors (IP3R) and their relatives, ryanodine receptors, are
the channels that most often mediate Ca2+ release from intracellular stores. Their regulation …

A rise in cytosolic Ca 2+ concentration is used as a universal signalling mechanism to
control biological processes as diverse as exocytosis, contraction, cell growth and cell …

Acute modulation of P/Q-type (α1A) calcium channels by neuronal activity-dependent
changes in intracellular Ca2+ concentration may contribute to short-term synaptic plasticity …