Amino acids (AAs) are key structural motifs with widespread applications in organic
synthesis, biochemistry, and material sciences. Recently, with the development of milder …

Radical thiol-ene chemistry has been demonstrated for a range of applications in peptide
science, including macrocyclization, glycosylation and lipidation amongst a myriad of others …

Radical reactions play an important role in modern organic synthetic chemistry. The
generation of carbon radicals from the homolytic cleavage of carbon–metal bonds has been …

C-Glycosyl peptides possess excellent metabolic stability and therapeutic properties and
thus play critical roles in biological studies as well as drug discoveries. However, the limited …

Most peptide drugs contain non-proteinogenic amino acids (NPAAs), born out through
extensive structure–activity relationship (SAR) studies using solid-phase peptide synthesis …

An iron-catalyzed alkylazidation of dehydroamino acids using peroxides as alkyl radical
precursors is described. Non-natural azidated amino esters bearing an α-alkyl chain could …

Lipopeptides are an important class of biomolecules for drug development. Compared with
conventional acylation, a chemoselective lipidation strategy offers a more efficient strategy …

Herein we present a highly efficient, light-mediated, deoxygenative protocol to access γ-oxo-
α-amino acid derivatives. This radical methodology employs photoredox catalysis, in …

Sulfur centered radicals are widely employed in chemical synthesis, in particular for alkene
and alkyne hydrothiolation towards thioether bioconjugates. The steadfast radical chain …

A s one of the most common unnatural amino acids (uAAs), α, β-dehydroamino acids (α, β-
dhAAs) can be found in various ribosomally synthesized and post-translationally modified …