Rheumatoid arthritis (RA) is a chronic immune-mediated disease that primarily affects the
synovium of diarthrodial joints. During the course of RA, the synovium transforms into a …

Cancers are not composed merely of cancer cells alone; instead, they are complex
'ecosystems' comprising many different cell types and noncellular factors. The tumour stroma …

Arthritis typically involves recurrence and progressive worsening at specific predilection
sites, but the checkpoints between remission and persistence remain unknown. Here, we …

The ability to rapidly restore the integrity of a broken skin barrier is critical and is the ultimate
goal of therapies for hard-to-heal-ulcers. Unfortunately effective treatments to enhance …

Inflammation and its resolution is under-studied in medicine despite being essential for
understanding the development of chronic inflammatory disease. In this review article, we …

In recent years, there has been an explosion of interest in how fibroblasts initiate, sustain,
and resolve inflammation across disease states. Fibroblasts contain heterogeneous subsets …

Wound healing is a dynamic and highly regulated process that can be separated into three
overlapping and interdependent phases: inflammation, proliferation, and remodelling. This …

Aging is a natural physiological process that features various and variable challenges,
associated with loss of homeostasis within the organism, often leading to negative …

Inflammation plays an important role in cardiac injuries. Here, we examined the role of
miRNA in regulating inflammation and cardiac injury during myocardial infarction. We …

Fibroblasts, which are traditionally recognized as a quiescent cell responsible for
extracellular matrix production, are more and more appreciated as an active key player of …