The essential toxin: impact of zinc on human health

LM Plum, L Rink, H Haase - … journal of environmental research and public …, 2010 - mdpi.com
Compared to several other metal ions with similar chemical properties, zinc is relatively
harmless. Only exposure to high doses has toxic effects, making acute zinc intoxication a …

The role of zinc in caspase activation and apoptotic cell death

AQ Truong-Tran, J Carter, RE Ruffin… - … and Homeostasis: Recent …, 2001 - Springer
In addition to its diverse role in many physiological systems, zinc (Zn) has now been shown
to be an important regulator of apoptosis. The purpose of this review is to integrate …

Trace mineral nutrition in poultry and swine

JD Richards, J Zhao, RJ Harrell, CA Atwell… - … Australasian Journal of …, 2010 - koreascience.kr
Trace minerals such as zinc, copper, and manganese are essential cofactors for hundreds of
cellular enzymes and transcription factors in all animal species, and thus participate in a …

[HTML][HTML] Zinc and gastrointestinal disease

S Skrovanek, K DiGuilio, R Bailey… - World journal of …, 2014 - ncbi.nlm.nih.gov
This review is a current summary of the role that both zinc deficiency and zinc
supplementation can play in the etiology and therapy of a wide range of gastrointestinal …

Zinc metabolism in airway epithelium and airway inflammation: basic mechanisms and clinical targets. A review

PD Zalewski, AQ Truong-Tran, D Grosser… - Pharmacology & …, 2005 - Elsevier
In addition to basic housekeeping roles in metalloenzymes and transcription factors, dietary
zinc (Zn) is an important immunoregulatory agent, growth cofactor, and cytoprotectant with …

Zinc and reproduction: effects of zinc deficiency on prenatal and early postnatal development

JY Uriu‐Adams, CL Keen - Birth Defects Research Part B …, 2010 - Wiley Online Library
A large body of evidence supports the concept that human pregnancy outcome is
significantly influenced by the nutritional status of the mother. The consumption of “poor …

Zinc deficiency and therapeutic value of zinc supplementation in pediatric gastrointestinal diseases

HC Chao - Nutrients, 2023 - mdpi.com
The benefits of zinc in treating certain gastrointestinal (GI) diseases have been recognized
for over two decades. This review aims to explore zinc deficiency (ZD) and the potential …

Apoptosis in the normal and inflamed airway epithelium: role of zinc in epithelial protection and procaspase-3 regulation

AQ Truong-Tran, D Grosser, RE Ruffin, C Murgia… - Biochemical …, 2003 - Elsevier
The epithelium lining the airways is a physical barrier as well as a regulator of physiological
and pathological events in the respiratory system. Damage to the epithelium by oxidants …

Reactive oxygen species in modulating intestinal stem cell dynamics and function

A Nath, P Chakrabarti, S Sen, A Barui - Stem Cell Reviews and Reports, 2022 - Springer
Frequent exposure to mechanistic damages, pathological ingression, and chronic
inflammation leads to recurrent cell death in the gut epithelium. Intestinal stem cells (ISCs) …

Chronic blockade of nitric oxide synthesis reduces adiposity and improves insulin resistance in high fat-induced obese mice

K Tsuchiya, H Sakai, N Suzuki, F Iwashima… - …, 2007 - academic.oup.com
Genetic deletion of inducible nitric oxide synthase (NOS) in mice has been shown to
improve high-fat diet (HFD)-induced insulin resistance. However, a pathophysiological role …