Post-translational modifications are at the apex of cellular communication and eventually
regulate every aspect of life. The identification of new post-translational modifiers is opening …

Post-translational modifications of cellular substrates with ubiquitin and ubiquitin-like
proteins (UBLs), including ubiquitin, SUMOs, and neural precursor cell–expressed …

Post-translational modifications (PTMs) add a major degree of complexity to the proteome
and are essential controllers of protein homeostasis. Amongst the hundreds of PTMs …

Besides ubiquitin (Ub), humans have a set of ubiquitin-like proteins (UBLs) that can also
covalently modify target proteins. To date, less is known about UBLs than Ub and even less …

Ubiquitin Fold Modifier‐1 (UFM1) is a ubiquitin‐like modifier (UBL) that is posttranslationally
attached to lysine residues on substrates via a dedicated system of enzymes conserved in …

Ufmylation is a post-translational modification essential for regulating key cellular processes.
A three-enzyme cascade involving E1, E2 and E3 is required for UFM1 attachment to target …

Ubiquitin-fold modifier 1 (UFM1) is a newly identified ubiquitin-like protein that has been
conserved during the evolution of multicellular organisms. In a similar manner to ubiquitin …

Protein UFMylation downstream of the E1 enzyme UBA5 plays essential roles in
development and endoplasmic reticulum stress. Variants in the UBA5 gene are associated …

Receptor tyrosine kinases (RTKs) are membrane-based sensors that enable rapid
communication between cells and their environment. Evidence is now emerging that …

Post-translational modification with Ubiquitin-like proteins represents a complex signaling
language regulating virtually every cellular process. Among these post-translational …