Dysregulated lipid metabolism represents an important metabolic alteration in cancer. Fatty
acids, cholesterol, and phospholipid are the three most prevalent lipids that act as energy …

Stem cell therapy is widely recognized as a promising strategy for exerting therapeutic
effects after injury in degenerative diseases. However, limitations such as low cell retention …

Sickle cell anemia (SCA) is a hereditary blood disorder characterized by the presence of
abnormal hemoglobin, leading to the formation of sickle-shaped red blood cells. While much …

Lysophosphatidic acid (LPA) is a bioactive lipid which increases in concentration locally and
systemically across different cancer types. Yet, the exact mechanism (s) of how LPA affects …

Acute myeloid leukemia (AML) kills 75% of patients and represents a major clinical
challenge with a need to improve on current treatment approaches. Targeting sphingosine …

Liver cancer is one of the leading causes of death worldwide due to late diagnosis and
scarcity of treatment options. The major risk factor for liver cancer is cirrhosis with the …

Since the clear demonstration of lysophosphatidic acid (LPA)'s pathological roles in cancer
in the mid-1990s, more than 1000 papers relating LPA to various types of cancer were …

Despite the use of high-resolution molecular techniques for tissue typing, chronic graft-
versus-host disease (cGVHD) remains a major complication following allogeneic …

This study was designed to explore whether exosomal sphingosine 1‐phosphate (S1P) from
mesenchymal stem cells (MSCs) regulate the Treg/Th17 balance in aplastic anemia (AA) …

Pluripotent stem cells (PSCs) can be maintained in a continuum of cellular states with
distinct features. Exogenous lipid supplements can relieve the dependence on de novo …