Post-translational acetylation of lysine residues has emerged as a key regulatory
mechanism in all eukaryotic organisms. Originally discovered in 1963 as a unique …

One of the most explored therapeutic approaches aimed at eradicating HIV-1 reservoirs is
the “shock and kill” strategy which is based on HIV-1 reactivation in latently-infected cells …

Histone acetylation is a diagnostic feature of transcriptionally active genes. The proper
recruitment and function of histone acetyltransferases (HATs) and deacetylases (HDACs) …

Combination antiretroviral therapy, despite being potent and life-prolonging, is not curative
and does not eradicate HIV-1 infection since interruption of treatment inevitably results in a …

Reversing HIV-1 latency promotes killing of infected cells and is essential for cure strategies;
however, no single latency reversing agent (LRA) or LRA combination have been shown to …

Latent HIV proviruses are silenced as the result of deacetylation and methylation of histones
located at the viral long terminal repeat (LTR). Inhibition of histone deacetylases (HDACs) …

HIV-1 can infect both activated and resting, non-dividing cells, following which the viral
genome can be permanently integrated into a host cell chromosome. Latent HIV-1 reservoirs …

The malaria parasite Plasmodium falciparum undergoes antigenic variation to evade host
immune responses through switching expression of variant surface proteins encoded by the …

Objective: We aimed to compare the potential for inducing HIV production and the effect on T-
cell activation of potent HDAC inhibitors undergoing clinical investigation. Design: In vitro …

Elucidating the mechanism of human immunodeficiency virus, type 1 (HIV-1) provirus
transcriptional silencing in latently infected cells is crucial for understanding the …