Psychobiological factors of resilience and depression in late life

KT Laird, B Krause, C Funes, H Lavretsky - Translational psychiatry, 2019 - nature.com
In contrast to traditional perspectives of resilience as a stable, trait-like characteristic,
resilience is now recognized as a multidimentional, dynamic capacity influenced by life-long …

Brain-derived neurotrophic factor and major depressive disorder: evidence from meta-analyses

T Kishi, R Yoshimura, T Ikuta, N Iwata - Frontiers in psychiatry, 2018 - frontiersin.org
Accumulating evidence suggests that brain-derived neurotrophic factor (BDNF) is
associated with the pathophysiology of major depressive disorder (MDD). In this mini review …

Characterizing heterogeneity in neuroimaging, cognition, clinical symptoms, and genetics among patients with late-life depression

J Wen, CHY Fu, D Tosun, Y Veturi, Z Yang… - JAMA …, 2022 - jamanetwork.com
Importance Late-life depression (LLD) is characterized by considerable heterogeneity in
clinical manifestation. Unraveling such heterogeneity might aid in elucidating etiological …

Genetics of resilience: Implications from genome‐wide association studies and candidate genes of the stress response system in posttraumatic stress disorder and …

S Maul, I Giegling, C Fabbri, F Corponi… - American Journal of …, 2020 - Wiley Online Library
Resilience is the ability to cope with critical situations through the use of personal and
socially mediated resources. Since a lack of resilience increases the risk of developing …

Neural substrates for late-life depression: a selective review of structural neuroimaging studies

YK Kim, KM Han - Progress in Neuro-Psychopharmacology and …, 2021 - Elsevier
Recent neuroimaging studies have characterized the pathophysiology of late-life depression
(LLD) as a dysfunction of the brain networks involved in the regulation of emotion …

Late-life depression: Epidemiology, phenotype, pathogenesis and treatment before and during the COVID-19 pandemic

Y Zhao, X Wu, M Tang, L Shi, S Gong, X Mei… - Frontiers in …, 2023 - frontiersin.org
Late-life depression (LLD) is one of the most common mental disorders among the older
adults. Population aging, social stress, and the COVID-19 pandemic have significantly …

Mild behavioral impairment in early Alzheimer's disease and its association with APOE and BDNF risk genetic polymorphisms

V Matuskova, K Veverova, DJ Jester, V Matoska… - Alzheimer's Research & …, 2024 - Springer
Background Mild behavioral impairment (MBI) has been commonly reported in early
Alzheimer's disease (AD) but rarely using biomarker-defined samples. It is also unclear …

Late life depression: The essentials and the essential distinctions

S Husain-Krautter, JM Ellison - Focus, 2021 - Am Psychiatric Assoc
Late life depression (LLD), a familiar syndrome, is not differentiated in the DSM-5. LLD can
resemble depressive syndromes in younger adults but it differs in demographic …

Neurotrophin crosstalk in the etiology and treatment of neuropsychiatric and neurodegenerative disease

R Joshi, SRJ Salton - Frontiers in Molecular Neuroscience, 2022 - frontiersin.org
This article reviews the current progress in our understanding of the mechanisms by which
growth factors, including brain-derived neurotrophic factor (BDNF) and vascular endothelial …

Shared genetic risk factors for depression and stroke

F Zhao, Y Yue, H Jiang, Y Yuan - Progress in Neuro-Psychopharmacology …, 2019 - Elsevier
Background The comorbidity of major depressive disorder (MDD) and stroke are common in
clinic. There is a growing body of evidence suggesting a bi-directional relationship between …