Regulating the depth of hypnosis during surgery is one of the major objectives of an
anesthesia infusion system. Continuous administration of Propofol infusion during surgical …

Anaesthesia is a multivariable problem where a combination of drugs are used to induce
desired hypnotic, analgesia and immobility states. The automation of anaesthesia may …

In this paper, a reinforcement learning (RL)-based optimal adaptive control approach is
proposed for the continuous infusion of a sedative drug to maintain a required level of …

The thesis discusses closed-loop control of the hypnotic and the analgesic components of
anesthesia. The objective of the work has been to develop a system which independently …

Continuous adjustment of Propofol in manual delivery of anesthesia for conducting a
surgical procedure overburdens the workload of an anesthetist who is working in a multi …

Regulation of hypnosis level on bi‐spectral index monitor (BIS) during a surgical procedure
in propofol anaesthesia administration is a challenging task for an anaesthesiologist in multi …

In this paper, a nonovershooting tracking controller is proposed for the continuous infusion
of multiple drugs that have interactive effects. The proposed controller design method …

Closed-loop controlled drug dosing has the potential of revolutionizing clinical anesthesia.
However, inter-patient variability in drug sensitivity poses a central challenge to the …

Pharmacometric modeling plays an important role in drug development and personalized
medicine. Pharmacometric covariate models can be used to describe the relationships …

This thesis investigates the design and performance of a model predictive controller (MPC)
for the automatic control of hypnosis. It constitutes the first step towards automatic control of …