Meiosis is the chromosomal foundation of reproduction, with errors in this important process
leading to aneuploidy and/or infertility. In this review celebrating the 50th anniversary of the …

BACKGROUND Meiosis is an essential stage in the life cycle of sexually reproducing
species, underlying formation of haploid gametes and serving as the basis of genetic …

In mammalian male meiosis, the heterologous X and Y chromosomes remain unsynapsed
and, as a result, are subject to meiotic sex chromosome inactivation (MSCI). MSCI is …

Meiotic synapsis and recombination ensure correct homologous segregation and genetic
diversity. Asynapsed homologs are transcriptionally inactivated by meiotic silencing, which …

Meiotic sex chromosome inactivation (MSCI) is an essential process in the male germline.
While genetic experiments have established that the DNA damage response (DDR) …

PURPOSE Homologous recombination DNA repair deficiency (HRD) is associated with
sensitivity to platinum and poly (ADP-ribose) polymerase inhibitors in certain cancer types …

We review how epigenetics affect sex chromosome evolution in animals and plants. In a few
species, sex is determined epigenetically through the action of Y-encoded small RNAs …

Meiotic sex chromosome inactivation (MSCI) is an essential event in the mammalian male
germline. MSCI is directed by a DNA damage response (DDR) pathway centered on the …

The Y has been described as a wimpy degraded relic of the X, with imminent demise should
it lose sex-determining function. Why then has it persisted in almost all mammals? Here we …

Meiotic recombination between homologous chromosomes is initiated by the formation of
hundreds of programmed double-strand breaks (DSBs). Approximately 10% of these DSBs …